NVL (gene)

Nuclear valosin-containing protein-like is a protein that in humans is encoded by the NVL gene.[5][6]

NVL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X8A
Identifiers
Aliases	NVL, NVL2, nuclear VCP-like, nuclear VCP like
External IDs	OMIM: 602426 MGI: 1914709 HomoloGene: 1902 GeneCards: NVL
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.11 Start 224,227,334 bp[1] End 224,330,189 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 181,087,138 bp[2] End 181,144,204 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • preribosome binding • GO:0001948 protein binding • ATP binding • RNA binding • ATPase activity Cellular component • nucleolus • membrane • cell nucleus • telomerase holoenzyme complex • nucleoplasm • nuclear exosome (RNase complex) Biological process • ribosome biogenesis • positive regulation of telomerase activity • rRNA processing • positive regulation of protein binding • ribosomal large subunit biogenesis • regulation of protein localization to nucleolus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4931	67459
Ensembl	ENSG00000143748	ENSMUSG00000026516
UniProt	O15381	Q9DBY8
RefSeq (mRNA)	NM_001243146 NM_001243147 NM_002533 NM_206840	NM_026171
RefSeq (protein)	NP_001230075 NP_001230076 NP_002524 NP_996671	NP_080447
Location (UCSC)	Chr 1: 224.23 – 224.33 Mb	Chr 1: 181.09 – 181.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000143748 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026516 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Germain-Lee EL, Obie C, Valle D (Nov 1997). "NVL: a new member of the AAA family of ATPases localized to the nucleus". Genomics. 44 (1): 22–34. doi:10.1006/geno.1997.4856. PMID 9286697.
6. "Entrez Gene: NVL nuclear VCP-like".

Further reading

• Nagahama M, Yamazoe T, Hara Y, et al. (2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1". Biochem. Biophys. Res. Commun. 346 (3): 1075–82. doi:10.1016/j.bbrc.2006.06.017. PMID 16782053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nagahama M, Hara Y, Seki A, et al. (2005). "NVL2 Is a Nucleolar AAA-ATPase that Interacts with Ribosomal Protein L5 through Its Nucleolar Localization Sequence". Mol. Biol. Cell. 15 (12): 5712–23. doi:10.1091/mbc.E04-08-0692. PMC 532049. PMID 15469983.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.