NUFIP1

Nuclear fragile X mental retardation-interacting protein 1 is a protein that in humans is encoded by the NUFIP1 gene.[5][6][7]

NUFIP1
Identifiers
Aliases	NUFIP1, NUFIP, bA540M5.1, FMR1 interacting protein 1, nuclear FMR1 interacting protein 1, Rsa1
External IDs	OMIM: 604354 MGI: 1351474 HomoloGene: 8216 GeneCards: NUFIP1
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.12 Start 44,939,249 bp[1] End 44,989,471 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 76,110,891 bp[2] End 76,137,379 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • ATPase binding • identical protein binding • protein binding, bridging • snoRNA binding • RNA binding • metal ion binding • DNA binding • nucleic acid binding Cellular component • nuclear matrix • cell nucleus • pre-snoRNP complex • perichromatin fibrils • nucleolus • cytosolic ribosome • transcription elongation factor complex • fibrillar center • presynaptic active zone • macromolecular complex • synapse Biological process • box C/D snoRNP assembly • positive regulation of transcription from RNA polymerase II promoter • RNA processing • protein oligomerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26747	27275
Ensembl	ENSG00000083635	ENSMUSG00000022009
UniProt	Q9UHK0	Q9QXX8
RefSeq (mRNA)	NM_012345	NM_013745
RefSeq (protein)	NP_036477	NP_038773
Location (UCSC)	Chr 13: 44.94 – 44.99 Mb	Chr 14: 76.11 – 76.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

NUFIP1 has been shown to interact with:

• BRCA1,[8]
• Cyclin T1,[8] and
• FMR1.[5][9]

References

1. GRCh38: Ensembl release 89: ENSG00000083635 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022009 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bardoni B, Schenck A, Mandel JL (Jan 2000). "A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein". Hum Mol Genet. 8 (13): 2557–66. doi:10.1093/hmg/8.13.2557. PMID 10556305.
6. Bardoni B, Giglio S, Schenck A, Rocchi M, Mandel JL (Aug 2000). "Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to chromosome 13q14 and assignment of a pseudogene to chromosome 6q12". Cytogenet Cell Genet. 89 (1–2): 11–3. doi:10.1159/000015580. PMID 10894927.
7. "Entrez Gene: NUFIP1 nuclear fragile X mental retardation protein interacting protein 1".
8. Cabart P, Chew HK, Murphy S (Jul 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825.
9. Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL (Jul 2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692.

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Cabart P, Chew HK, Murphy S (2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825.
• Bardoni B, Willemsen R, Weiler IJ, Schenck A, Severijnen LA, Hindelang C, Lalli E, Mandel JL (2003). "NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes". Exp. Cell Res. 289 (1): 95–107. doi:10.1016/S0014-4827(03)00222-2. PMID 12941608.
• Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL (2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692.