Netrin G1

Netrin-G1 is a protein that in humans is encoded by the NTNG1 gene.[5][6]

NTNG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZYJ
Identifiers
Aliases	NTNG1, Lmnt1, netrin G1
External IDs	OMIM: 608818 MGI: 1934028 HomoloGene: 8949 GeneCards: NTNG1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 107,140,007 bp[1] End 107,483,458 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 109,780,040 bp[2] End 110,144,011 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • cell adhesion molecule binding • protein binding involved in cell-cell adhesion Cellular component • anchored component of membrane • anchored component of plasma membrane • membrane • extracellular region • cell membrane • Schaffer collateral - CA1 synapse • glutamatergic synapse • anchored component of presynaptic active zone membrane Biological process • multicellular organism development • cell differentiation • axonogenesis • nervous system development • C-terminal protein lipidation • modulation of chemical synaptic transmission • synaptic membrane adhesion • motor neuron axon guidance • animal organ morphogenesis • histogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22854	80883
Ensembl	ENSG00000162631	ENSMUSG00000059857
UniProt	Q9Y2I2	Q8R4G0
RefSeq (mRNA)	NM_001113226 NM_001113228 NM_001312688 NM_014917 NM_001330665 NM_001372166 NM_001372167 NM_001372168 NM_001372169 NM_001372170 NM_001372171	NM_001163348 NM_001163349 NM_001163350 NM_001163351 NM_030699 NM_133488
RefSeq (protein)	NP_001106697 NP_001106699 NP_001299617 NP_001317594 NP_055732 NP_001359095 NP_001359096 NP_001359097 NP_001359098 NP_001359099 NP_001359100	NP_001156820 NP_001156821 NP_001156822 NP_109624 NP_597995
Location (UCSC)	Chr 1: 107.14 – 107.48 Mb	Chr 3: 109.78 – 110.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Netrin G1 (NTNG1) belongs to a conserved family of proteins that act as axon guidance cues during vertebrate nervous system development (Nakashiba et al., 2000).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000162631 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059857 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakashiba T, Ikeda T, Nishimura S, Tashiro K, Honjo T, Culotti JG, Itohara S (Sep 2000). "Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins". J Neurosci. 20 (17): 6540–50. doi:10.1523/JNEUROSCI.20-17-06540.2000. PMID 10964959.
6. "Entrez Gene: NTNG1 netrin G1".

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Lin JC, Ho WH, Gurney A, Rosenthal A (2004). "The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons". Nat. Neurosci. 6 (12): 1270–6. doi:10.1038/nn1148. PMID 14595443.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fukasawa M, Aoki M, Yamada K, et al. (2004). "Case-control association study of human netrin G1 gene in Japanese schizophrenia". J. Med. Dent. Sci. 51 (2): 121–8. PMID 15508520.
• Aoki-Suzuki M, Yamada K, Meerabux J, et al. (2005). "A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia". Biol. Psychiatry. 57 (4): 382–93. doi:10.1016/j.biopsych.2004.11.022. PMID 15705354.
• Borg I, Freude K, Kübart S, et al. (2005). "Disruption of Netrin G1 by a balanced chromosome translocation in a girl with Rett syndrome". European Journal of Human Genetics. 13 (8): 921–7. doi:10.1038/sj.ejhg.5201429. PMID 15870826.
• Meerabux JM, Ohba H, Fukasawa M, et al. (2006). "Human netrin-G1 isoforms show evidence of differential expression". Genomics. 86 (1): 112–6. doi:10.1016/j.ygeno.2005.04.004. PMID 15901489.
• Archer HL, Evans JC, Millar DS, et al. (2006). "NTNG1 Mutations are a Rare Cause of Rett Syndrome". American Journal of Medical Genetics. 140 (7): 691–4. doi:10.1002/ajmg.a.31133. PMC 2577736. PMID 16502428.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Nectoux J, Girard B, Bahi-Buisson N, et al. (2007). "Netrin G1 mutations are an uncommon cause of atypical Rett syndrome with or without epilepsy". Pediatr. Neurol. 37 (4): 270–4. doi:10.1016/j.pediatrneurol.2007.06.002. PMID 17903671.