Netrin 1

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.[5][6]

NTN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4URT
Identifiers
Aliases	NTN1, NTN1L, netrin 1, MRMV4
External IDs	OMIM: 601614 MGI: 105088 HomoloGene: 21008 GeneCards: NTN1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 9,021,510 bp[1] End 9,244,000 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 68,209,364 bp[2] End 68,400,823 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • extracellular region • cytoplasm • basement membrane Biological process • mammary gland duct morphogenesis • positive regulation of cell motility • axon guidance • substrate-dependent cell migration, cell extension • Cdc42 protein signal transduction • positive regulation of axon extension • inner ear morphogenesis • negative regulation of axon extension • apoptotic process • mammary gland development • positive regulation of cell proliferation • regulation of cell migration • Ras protein signal transduction • anterior/posterior axon guidance • neuron migration • axonogenesis • nuclear migration • cell-cell adhesion • negative regulation of netrin-activated signaling pathway • regulation of synapse assembly • chemorepulsion of axon • motor neuron axon guidance • animal organ morphogenesis • histogenesis • dendrite development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9423	18208
Ensembl	ENSG00000065320	ENSMUSG00000020902
UniProt	O95631	O09118
RefSeq (mRNA)	NM_004822	NM_008744
RefSeq (protein)	NP_004813	NP_032770
Location (UCSC)	Chr 17: 9.02 – 9.24 Mb	Chr 11: 68.21 – 68.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.[6]

Interactions

NTN1 has been shown to interact with Deleted in Colorectal Cancer.[5][7]

References

1. GRCh38: Ensembl release 89: ENSG00000065320 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020902 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (January 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35–42. PMID 9950216.
6. "Entrez Gene: NTN1 netrin 1".
7. Geisbrecht, Brian V; Dowd Kimberly A; Barfield Ronald W; Longo Patti A; Leahy Daniel J (Aug 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. United States. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. ISSN 0021-9258. PMID 12810718.

Further reading

• Bouhidel JO, Wang P, Siu KL, Li H, Youn JY, Cai H (February 2015). "Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy". Biochim. Biophys. Acta. 1852 (2): 277–89. doi:10.1016/j.bbadis.2014.06.005. PMC 4262720. PMID 24928309.</ref>
• Arakawa H (2005). "Netrin-1 and its receptors in tumorigenesis". Nat. Rev. Cancer. 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119.
• Mehlen P, Furne C (2006). "Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis". Cell. Mol. Life Sci. 62 (22): 2599–616. doi:10.1007/s00018-005-5191-3. PMID 16158190.
• Keino-Masu K, Masu M, Hinck L, et al. (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor". Cell. 87 (2): 175–85. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
• Serafini T, Colamarino SA, Leonardo ED, et al. (1997). "Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system". Cell. 87 (6): 1001–14. doi:10.1016/S0092-8674(00)81795-X. PMID 8978605.
• Togari A, Mogi M, Arai M, et al. (2001). "Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts". Brain Res. 878 (1–2): 204–9. doi:10.1016/S0006-8993(00)02700-1. PMID 10996153.
• Corset V, Nguyen-Ba-Charvet KT, Forcet C, et al. (2000). "Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor". Nature. 407 (6805): 747–50. doi:10.1038/35037600. PMID 11048721.
• Manitt C, Colicos MA, Thompson KM, et al. (2001). "Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord". J. Neurosci. 21 (11): 3911–22. doi:10.1523/JNEUROSCI.21-11-03911.2001. PMC 6762706. PMID 11356879.
• Srinivasan K, Strickland P, Valdes A, et al. (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis". Dev. Cell. 4 (3): 371–82. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
• Yebra M, Montgomery AM, Diaferia GR, et al. (2003). "Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration". Dev. Cell. 5 (5): 695–707. doi:10.1016/S1534-5807(03)00330-7. PMID 14602071.
• Mazelin L, Bernet A, Bonod-Bidaud C, et al. (2004). "Netrin-1 controls colorectal tumorigenesis by regulating apoptosis". Nature. 431 (7004): 80–4. Bibcode:2004Natur.431...80M. doi:10.1038/nature02788. PMID 15343335.
• Kato HD, Kondoh H, Inoue T, et al. (2004). "Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis". Gynecol. Oncol. 95 (2): 281–9. doi:10.1016/j.ygyno.2004.07.050. PMID 15491747.
• Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation". J. Neurosci. 24 (48): 10826–34. doi:10.1523/JNEUROSCI.3715-04.2004. PMID 15574733.
• Hérincs Z, Corset V, Cahuzac N, et al. (2005). "DCC association with lipid rafts is required for netrin-1-mediated axon guidance". J. Cell Sci. 118 (Pt 8): 1687–92. doi:10.1242/jcs.02296. PMID 15811950.
• Kim TH, Lee HK, Seo IA, et al. (2005). "Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron". J. Neurochem. 95 (1): 1–8. doi:10.1111/j.1471-4159.2005.03314.x. PMC 2683579. PMID 16181408.
• Ly NP, Komatsuzaki K, Fraser IP, et al. (2006). "Netrin-1 inhibits leukocyte migration in vitro and in vivo". Proc. Natl. Acad. Sci. U.S.A. 102 (41): 14729–34. Bibcode:2005PNAS..10214729L. doi:10.1073/pnas.0506233102. PMC 1253572. PMID 16203981.

Varadarajan, Supraja G., et al. "Netrin1 produced by neural progenitors, not floor plate cells, is required for axon guidance in the spinal cord." Neuron 94.4 (2017): 790-799. https://doi.org/10.1016/j.neuron.2017.03.007

External links

• NTN1 human gene location in the UCSC Genome Browser.
• NTN1 human gene details in the UCSC Genome Browser.