NRK (gene)

Nik-related protein kinase is an enzyme that, in humans, is encoded by the NRK gene.[5]

NRK
Identifiers
Aliases	NRK, NESK, Nik related kinase
External IDs	OMIM: 300791 MGI: 1351326 HomoloGene: 8442 GeneCards: NRK
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.3 Start 105,822,539 bp[1] End 105,958,610 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F1|X 61.15 cM Start 138,914,430 bp[2] End 139,010,532 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • ATP binding • kinase activity • protein serine/threonine kinase activity • MAP kinase kinase kinase kinase activity Cellular component • cytoplasm Biological process • protein phosphorylation • activation of JNKK activity • regulation of spongiotrophoblast cell proliferation • birth • phosphorylation • negative regulation of cell proliferation • activation of MAPKKK activity • regulation of mitotic cell cycle • stress-activated protein kinase signaling cascade • regulation of apoptotic process • neuron projection morphogenesis • MAPK cascade • signal transduction by protein phosphorylation • actin cytoskeleton reorganization • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	203447	27206
Ensembl	ENSG00000123572	ENSMUSG00000052854
UniProt	Q7Z2Y5	Q9R0G8
RefSeq (mRNA)	NM_198465	NM_013724
RefSeq (protein)	NP_940867	NP_038752
Location (UCSC)	Chr X: 105.82 – 105.96 Mb	Chr X: 138.91 – 139.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000123572 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052854 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NRK Nik related kinase".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakano K, Kanai-Azuma M, Kanai Y, et al. (2003). "Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family". Exp. Cell Res. 287 (2): 219–27. doi:10.1016/S0014-4827(03)00136-8. PMID 12837278.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.