NPTXR

Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.[5][6]

NPTXR
Identifiers
Aliases	NPTXR, NPR, neuronal pentraxin receptor
External IDs	OMIM: 609474 MGI: 1920590 HomoloGene: 8620 GeneCards: NPTXR
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,818,452 bp[1] End 38,844,028 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.85 cM Start 79,786,351 bp[2] End 79,804,766 bp[2]
Gene ontology Molecular function • metal ion binding Cellular component • membrane • integral component of membrane • cell membrane • cytoplasmic side of plasma membrane • filopodium • dendrite • growth cone • neuronal cell body • glutamatergic synapse Biological process • neuron projection development • regulation of postsynaptic neurotransmitter receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23467	73340
Ensembl	ENSG00000221890	ENSMUSG00000022421
UniProt	O95502	Q99J85
RefSeq (mRNA)	NM_058178 NM_014293	NM_030689
RefSeq (protein)	NP_055108	n/a
Location (UCSC)	Chr 22: 38.82 – 38.84 Mb	Chr 15: 79.79 – 79.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.[6]

See also

• NPTX2, Neuronal pentraxin II

References

1. GRCh38: Ensembl release 89: ENSG00000221890 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022421 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G (Feb 2006). "Regulation of neuronal type genes in congestive heart failure rats". Acta Physiol (Oxf). 186 (1): 17–27. doi:10.1111/j.1748-1716.2005.01503.x. PMID 16497176.
6. "Entrez Gene: NPTXR neuronal pentraxin receptor".

Further reading

• Poulsen TT, Pedersen N, Perin MS, et al. (2006). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin". Lung Cancer. 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.