NOSIP

Nitric oxide synthase-interacting protein is an enzyme that in humans is encoded by the NOSIP gene.[5][6][7]

NOSIP
Identifiers
Aliases	NOSIP, CGI-25, nitric oxide synthase interacting protein
External IDs	OMIM: 616759 MGI: 1913644 HomoloGene: 9315 GeneCards: NOSIP
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,555,468 bp[1] End 49,590,262 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,062,429 bp[2] End 45,078,210 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • transferase activity • RNA binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cellular component • cytoplasm • cytosol • Golgi membrane • cell nucleus Biological process • GO:0048553 negative regulation of catalytic activity • negative regulation of nitric-oxide synthase activity • multicellular organism development • protein ubiquitination • regulation of nitric-oxide synthase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51070	66394
Ensembl	ENSG00000142546	ENSMUSG00000003421
UniProt	Q9Y314	Q9D6T0
RefSeq (mRNA)	NM_001270960 NM_015953 NM_001363649	NM_001163684 NM_025533
RefSeq (protein)	NP_001257889 NP_057037 NP_001350578	NP_001157156 NP_079809
Location (UCSC)	Chr 19: 49.56 – 49.59 Mb	Chr 7: 45.06 – 45.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000142546 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003421 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dedio J, Konig P, Wohlfart P, Schroeder C, Kummer W, Muller-Esterl W (Jan 2001). "NOSIP, a novel modulator of endothelial nitric oxide synthase activity". FASEB J. 15 (1): 79–89. doi:10.1096/fj.00-0078com. PMID 11149895.
6. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
7. "Entrez Gene: NOSIP nitric oxide synthase interacting protein".

Further reading

• Schleicher M, Brundin F, Gross S, et al. (2005). "Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton". Mol. Cell. Biol. 25 (18): 8251–8. doi:10.1128/MCB.25.18.8251-8258.2005. PMC 1234313. PMID 16135813.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Dreyer J, Schleicher M, Tappe A, et al. (2005). "Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity". J. Neurosci. 24 (46): 10454–65. doi:10.1523/JNEUROSCI.2265-04.2004. PMID 15548660.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.