NKRF (gene)

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.[5][6]

NKRF
Identifiers
AliasesNKRF, ITBA4, NRF, NFKB repressing factor
External IDsOMIM: 300440 MGI: 1924536 HomoloGene: 84816 GeneCards: NKRF
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq24Start119,588,337 bp[1]
End119,606,443 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55922

77286

Ensembl

ENSG00000186416

ENSMUSG00000044149

UniProt

O15226

Q8BY02

RefSeq (mRNA)

NM_001173487
NM_001173488
NM_017544

NM_029891

RefSeq (protein)

NP_060014

NP_084167

Location (UCSC)Chr X: 119.59 – 119.61 MbChr X: 36.89 – 36.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes.

The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000186416 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044149 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553.
  6. "Entrez Gene: NKRF NF-kappaB repressing factor".

Further reading


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