NFKBIE

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.[5][6]

NFKBIE
Identifiers
AliasesNFKBIE, IKBE, NFKB inhibitor epsilon
External IDsOMIM: 604548 MGI: 1194908 HomoloGene: 36160 GeneCards: NFKBIE
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.1Start44,258,166 bp[1]
End44,265,788 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4794

18037

Ensembl

ENSG00000146232

ENSMUSG00000023947

UniProt

O00221

O54910

RefSeq (mRNA)

NM_004556

NM_008690
NM_001304956

RefSeq (protein)

NP_004547

NP_001291885
NP_032716

Location (UCSC)Chr 6: 44.26 – 44.27 MbChr 17: 45.56 – 45.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins.[6]

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1).[5]

Interactions

NFKBIE has been shown to interact with NFKB2,[7] RELA,[7] NFKB1[7] and REL.[7][8][9]

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gollark: File writing example:```lualocal f = fs.open("file", "a") -- open "file" in a (append) modef.writeLine(line_to_write) -- write line to the filef.flush() -- write line to disk```
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References
  1. GRCh38: Ensembl release 89: ENSG00000146232 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023947 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon".
  6. Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156.
  7. Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. United States. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. ISSN 0270-7306. PMC 232469. PMID 9315679.
  8. Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. United States. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi:10.1073/pnas.90.19.8962. ISSN 0027-8424. PMC 47481. PMID 8415639.
  9. Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. United States. 164 (6): 3316–22. doi:10.4049/jimmunol.164.6.3316. ISSN 0022-1767. PMID 10706725.

Further reading


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