NEMF (gene)

NEMF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J92
Identifiers
Aliases	NEMF, NY-CO-1, SDCCAG1, nuclear export mediator factor
External IDs	OMIM: 608378 MGI: 1918305 HomoloGene: 3458 GeneCards: NEMF
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	49,852,821 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	69,357,165 bp[2]
Gene ontology
Molecular function	• tRNA binding; • ribosomal large subunit binding;
Cellular component	• cell nucleus; • RQC complex;
Biological process	• nuclear export; • rescue of stalled ribosome; • ribosome-associated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9147
	66244
	ENSG00000165525
	ENSMUSG00000020982
	O60524
	Q8CCP0
	NM_001301732; NM_004713
	NM_025441; NM_181665
	NP_001288661; NP_004704
	NP_079717
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.[5]

Function

This gene encodes a component of the ribosome quality control complex.[6] The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor.

References

GRCh38: Ensembl release 89: ENSG00000165525 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020982 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Nuclear export mediator factor".
Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881. PMID 25578875.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165525 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020982 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nuclear export mediator factor".

[Shao_Brown_Santhanam_Hegde_2015_pp._433–444-6] Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881. PMID 25578875.