NELL2

Protein kinase C-binding protein NELL2 is an enzyme that in humans is encoded by the NELL2 gene.[5]

NELL2
Identifiers
Aliases	NELL2, NRP2, neural EGFL like 2
External IDs	OMIM: 602320 MGI: 1858510 HomoloGene: 4488 GeneCards: NELL2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q12 Start 44,508,275 bp[1] End 44,921,848 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 95,075,230 bp[2] End 95,528,559 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • GO:0001948 protein binding • protein kinase C binding • heparin binding Cellular component • extracellular region • cell • cytoplasm Biological process • neuron cellular homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4753	54003
Ensembl	ENSG00000184613	ENSMUSG00000022454
UniProt	Q99435	Q61220
RefSeq (mRNA)	NM_001145107 NM_001145108 NM_001145109 NM_001145110 NM_006159	NM_001289653 NM_016743 NM_001356950 NM_001356951
RefSeq (protein)	NP_001138579 NP_001138580 NP_001138581 NP_001138582 NP_006150	NP_001276582 NP_001343879 NP_001343880
Location (UCSC)	Chr 12: 44.51 – 44.92 Mb	Chr 15: 95.08 – 95.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full length sequence has not been determined.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000184613 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022454 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NELL2 NEL-like 2 (chicken)".

Further reading

• Watanabe TK, Katagiri T, Suzuki M, et al. (1997). "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats". Genomics. 38 (3): 273–6. doi:10.1006/geno.1996.0628. PMID 8975702.
• Beckmann G, Hanke J, Bork P, Reich JG (1998). "Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins". J. Mol. Biol. 275 (5): 725–30. doi:10.1006/jmbi.1997.1510. PMID 9480764.
• Luce MJ, Burrows PD (1999). "The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage". Gene. 231 (1–2): 121–6. doi:10.1016/S0378-1119(99)00093-1. PMID 10231576.
• Kuroda S, Oyasu M, Kawakami M, et al. (1999). "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2". Biochem. Biophys. Res. Commun. 265 (1): 79–86. doi:10.1006/bbrc.1999.1638. PMID 10548494.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.