NDRG2

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstream-regulated gene 2).[5][6]

NDRG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XMQ, 2XMR, 2XMS
Identifiers
Aliases	NDRG2, SYLD, NDRG family member 2
External IDs	OMIM: 605272 MGI: 1352498 HomoloGene: 22785 GeneCards: NDRG2
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 21,016,763 bp[1] End 21,070,872 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 51,905,271 bp[2] End 51,913,488 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • growth cone • cell nucleus • perinuclear region of cytoplasm • Golgi apparatus • cell projection • cytosol • extracellular exosome • cytoplasm Biological process • negative regulation of smooth muscle cell proliferation • regulation of vascular endothelial growth factor production • negative regulation of cytokine production • nervous system development • multicellular organism development • cell differentiation • substantia nigra development • Wnt signaling pathway • negative regulation of ERK1 and ERK2 cascade • regulation of platelet-derived growth factor production • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57447	29811
Ensembl	ENSG00000165795	ENSMUSG00000004558
UniProt	Q9UN36	Q9QYG0
RefSeq (mRNA)	NM_001282211 NM_001282212 NM_001282213 NM_001282214 NM_001282215 NM_001282216 NM_016250 NM_201535 NM_201536 NM_201537 NM_201538 NM_201539 NM_201540 NM_201541 NM_001320329 NM_001354559 NM_001354562 NM_001354566 NM_001354567 NM_001354568 NM_001354569 NM_001354570 NM_001354558 NM_001354560 NM_001354561 NM_001354564 NM_001354565	NM_001145959 NM_013864
RefSeq (protein)	NP_001269140 NP_001269141 NP_001269142 NP_001269143 NP_001269144 NP_001269145 NP_001307258 NP_057334 NP_963293 NP_963294 NP_963831 NP_963832 NP_963833 NP_963834 NP_963835 NP_001341488 NP_001341491 NP_001341495 NP_001341496 NP_001341497 NP_001341498 NP_001341499 NP_001341487 NP_001341489 NP_001341490 NP_001341493 NP_001341494	NP_001139431 NP_038892 NP_001347193 NP_001347194 NP_001347195 NP_001347196 NP_001347197 NP_001347198 NP_001347199 NP_001347200 NP_001347201 NP_001347202 NP_001347203 NP_001347205
Location (UCSC)	Chr 14: 21.02 – 21.07 Mb	Chr 14: 51.91 – 51.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma and aggressive meningioma carcinogenesis (via cell proliferation[7]).[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000165795 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004558 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK (Aug 2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom". Am J Hum Genet. 67 (1): 47–58. doi:10.1086/302978. PMC 1287101. PMID 10831399.
6. "Entrez Gene: NDRG2 NDRG family member 2".
7. Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC (September 2003). "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation". Int. J. Cancer. 106 (3): 342–7. doi:10.1002/ijc.11228. PMID 12845671.
8. Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A (August 2005). "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma". Cancer Res. 65 (16): 7121–6. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.

Further reading

• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
• Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol. Cell. Biochem. 229 (1–2): 35–44. doi:10.1023/A:1017934810825. PMID 11936845.
• Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev. Brain Res. 135 (1–2): 55–63. doi:10.1016/S0165-3806(02)00300-0. PMID 11978393.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deng Y, Yao L, Chau L, et al. (2003). "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation". Int. J. Cancer. 106 (3): 342–7. doi:10.1002/ijc.11228. PMID 12845671.
• Choi SC, Kim KD, Kim JT, et al. (2003). "Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells". FEBS Lett. 553 (3): 413–8. doi:10.1016/S0014-5793(03)01030-5. PMID 14572661.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.
• Mitchelmore C, Büchmann-Møller S, Rask L, et al. (2004). "NDRG2: a novel Alzheimer's disease associated protein". Neurobiol. Dis. 16 (1): 48–58. doi:10.1016/j.nbd.2004.01.003. PMID 15207261.
• Murray JT, Campbell DG, Morrice N, et al. (2005). "Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3". Biochem. J. 384 (Pt 3): 477–88. doi:10.1042/BJ20041057. PMC 1134133. PMID 15461589.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Hu XL, Liu XP, Lin SX, et al. (2005). "NDRG2 expression and mutation in human liver and pancreatic cancers". World J. Gastroenterol. 10 (23): 3518–21. doi:10.3748/wjg.v10.i23.3518. PMC 4576239. PMID 15526377.
• Devroe E, Silver PA, Engelman A (2005). "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases". Virology. 331 (1): 181–9. doi:10.1016/j.virol.2004.10.023. PMID 15582665.
• Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829.
• Lusis EA, Watson MA, Chicoine MR, et al. (2005). "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma". Cancer Res. 65 (16): 7121–6. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.