NDC1

Nucleoporin NDC1 is a protein that in humans is encoded by the TMEM48 gene.[5][6][7] It anchors aladin to the nuclear pore complex.[8]

NDC1
Identifiers
Aliases	NDC1, NET3, TMEM48, NDC1 transmembrane nucleoporin
External IDs	OMIM: 610115 MGI: 1920037 HomoloGene: 41224 GeneCards: NDC1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 53,765,478 bp[1] End 53,838,463 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 107,367,784 bp[2] End 107,416,346 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0005487 structural constituent of nuclear pore Cellular component • cytoplasm • integral component of membrane • nuclear membrane • nuclear envelope • membrane • cell membrane • nuclear pore • actin cytoskeleton • cell nucleus • spindle pole body • nuclear pore transmembrane ring • host cell Biological process • mRNA transport • nuclear pore complex assembly • nuclear pore distribution • viral transcription • protein sumoylation • mitotic nuclear envelope disassembly • synapsis • spermatogenesis • protein transport • regulation of cellular response to heat • GO:0022415 viral process • mRNA export from nucleus • GO:0046795 intracellular transport of virus • tRNA export from nucleus • spindle pole body duplication • regulation of gene silencing by miRNA • regulation of glycolytic process • transport • nuclear pore organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55706	72787
Ensembl	ENSG00000058804	ENSMUSG00000028614
UniProt	Q9BTX1	Q8VCB1
RefSeq (mRNA)	NM_001168551 NM_018087	NM_028355
RefSeq (protein)	NP_001162023 NP_060557	NP_082631
Location (UCSC)	Chr 1: 53.77 – 53.84 Mb	Chr 4: 107.37 – 107.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000058804 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028614 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lau CK, Delmar VA, Forbes DJ (Aug 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". Anat Rec A Discov Mol Cell Evol Biol. 288 (7): 681–94. doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.
6. Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (Sep 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. doi:10.1126/science.1088176. PMID 12958361.
7. "Entrez Gene: TMEM48 transmembrane protein 48".
8. Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (December 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID 19782045.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells". Mol. Cell. 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
• Stavru F, Hülsmann BB, Spang A, et al. (2006). "NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes" (PDF). J. Cell Biol. 173 (4): 509–19. doi:10.1083/jcb.200601001. PMC 2063861. PMID 16702233.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.