NCDN

Neurochondrin (also known as its murine homologue, Norbin) is a protein that in humans is encoded by the NCDN gene.[5][6]

NCDN
Identifiers
Aliases	NCDN, neurochondrin
External IDs	OMIM: 608458 MGI: 1347351 HomoloGene: 8064 GeneCards: NCDN
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 35,557,473 bp[1] End 35,567,274 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 126,743,750 bp[2] End 126,753,438 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • neuron projection • axon • neuronal cell body • dendrite • cell projection • membrane • cell nucleus • cytosol Biological process • regulation of neuronal synaptic plasticity • neuron projection development • bone resorption Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23154	26562
Ensembl	ENSG00000020129	ENSMUSG00000028833
UniProt	Q9UBB6	Q9Z0E0
RefSeq (mRNA)	NM_014284 NM_001014839 NM_001014841	NM_011986 NM_001355412 NM_001355413
RefSeq (protein)	NP_001014839 NP_001014841 NP_055099	NP_036116 NP_001342341 NP_001342342
Location (UCSC)	Chr 1: 35.56 – 35.57 Mb	Chr 4: 126.74 – 126.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.[6]

Norbin can modulate signaling activity and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition.[7] Furthermore, norbin protein expression is altered in the schizophrenia brain.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000020129 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028833 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Istvánffy R, Vogt Weisenhorn DM, Floss T, Wurst W (Apr 2004). "Expression of neurochondrin in the developing and adult mouse brain". Development Genes and Evolution. 214 (4): 206–9. doi:10.1007/s00427-004-0396-2. PMID 15007648.
6. "Entrez Gene: NCDN neurochondrin".
7. Wang H, Westin L, Nong Y, Birnbaum S, Bendor J, Brismar H, Nestler E, Aperia A, Flajolet M, Greengard P (Dec 2009). "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling". Science. 326 (5959): 1554–7. Bibcode:2009Sci...326.1554W. doi:10.1126/science.1178496. PMC 2796550. PMID 20007903.
8. Matosin N, Fernandez-Enright F, Fung SJ, Lum JS, Engel M, Andrews JL, Huang XF, Weickert CS, Newell KA (Jul 2015). "Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation". Acta Neuropathologica. 130 (1): 119–29. doi:10.1007/s00401-015-1411-6. PMID 25778620.

Further reading

• Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, Sugiyama F, Tanimoto K, Yagami K, Imai H, Fukamizu A (May 2005). "Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure". The Journal of Biological Chemistry. 280 (21): 20503–8. doi:10.1074/jbc.M414033200. PMID 15790563.
• Mochizuki R, Dateki M, Yanai K, Ishizuka Y, Amizuka N, Kawashima H, Koga Y, Ozawa H, Fukamizu A (Oct 2003). "Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality". Biochemical and Biophysical Research Communications. 310 (4): 1219–26. doi:10.1016/j.bbrc.2003.09.153. PMID 14559245.
• Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (Jan 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
• Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (Jan 2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75". Biochemical and Biophysical Research Communications. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505.
• Mochizuki R, Ishizuka Y, Yanai K, Murakami K, Koga Y, Fukamizu A (Feb 2000). "Corrigendum to 'Molecular cloning and expression of human neurochondrin-1 and -2'(1)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 367–8. doi:10.1016/s0167-4781(99)00236-5. PMID 10684983.
• Mochizuki R, Ishizuka Y, Yanai K, Koga Y, Fukamizu A, Murakami K (Sep 1999). "Molecular cloning and expression of human neurochondrin-1 and -2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (3): 397–402. doi:10.1016/s0167-4781(99)00120-7. PMID 10524216.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.