NBR1

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[5][6]

NBR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WJ6, 2BKF, 2CP8, 2G4S, 2L8J, 2MGW, 2MJ5, 4OLE
Identifiers
Aliases	NBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor, NBR1 autophagy cargo receptor
External IDs	OMIM: 166945 MGI: 108498 HomoloGene: 7438 GeneCards: NBR1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,170,481 bp[1] End 43,211,689 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 65.36 cM Start 101,552,149 bp[2] End 101,581,951 bp[2]
Gene ontology Molecular function • metal ion binding • zinc ion binding • GO:0001948 protein binding • mitogen-activated protein kinase binding • ubiquitin binding Cellular component • cytoplasm • M band • autophagosome • cytosol • late endosome • lysosome • extracellular exosome • membrane • cytoplasmic vesicle • pre-autophagosomal structure • mitochondrion • nucleoplasm • nuclear body • intracellular membrane-bounded organelle Biological process • protein oligomerization • negative regulation of osteoblast differentiation • regulation of stress-activated MAPK cascade • regulation of bone mineralization • macroautophagy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4077	17966
Ensembl	ENSG00000188554	ENSMUSG00000017119
UniProt	Q14596	P97432
RefSeq (mRNA)	NM_001291571 NM_001291572 NM_005899 NM_031858 NM_031862	NM_001252220 NM_001252222 NM_001252223 NM_008676
RefSeq (protein)	NP_001278500 NP_001278501 NP_005890 NP_114068	NP_001239149 NP_001239151 NP_001239152 NP_032702
Location (UCSC)	Chr 17: 43.17 – 43.21 Mb	Chr 11: 101.55 – 101.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[6] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.[7]

Interactions

NBR1 has been shown to interact with FEZ1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000188554 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017119 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
6. "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
7. Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell. 34 (3): 259–269. doi:10.1016/j.molcel.2009.04.026. PMID 19450525.
8. Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.

Further reading

• Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. Bibcode:1994Sci...266...66M. doi:10.1126/science.7545954. PMID 7545954.
• Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–1266. doi:10.1093/hmg/4.8.1259. PMID 7581362.
• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Brown MA, Nicolai H, Xu CF, et al. (1995). "Regulation of BRCA1". Nature. 372 (6508): 733. Bibcode:1994Natur.372..733B. doi:10.1038/372733a0. PMID 7997258.
• Brown MA, Xu CF, Nicolai H, et al. (1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21". Oncogene. 12 (12): 2507–13. PMID 8700509.
• Dimitrov S, Brennerova M, Forejt J (2001). "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene. 262 (1–2): 89–98. doi:10.1016/S0378-1119(00)00549-7. PMID 11179671.
• Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.
• Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lamark T, Perander M, Outzen H, et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins". J. Biol. Chem. 278 (36): 34568–34581. doi:10.1074/jbc.M303221200. PMID 12813044.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science. 308 (5728): 1599–1603. Bibcode:2005Sci...308.1599L. CiteSeerX 10.1.1.383.9888. doi:10.1126/science.1110463. PMID 15802564.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.