NANOS1

Nanos homolog 1 (Drosophila) is a protein that in humans is encoded by the NANOS1 gene.[5]

NANOS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CQO
Identifiers
Aliases	NANOS1, NOS1, SPGF12, EC_Rep1a, NOS-1, nanos homolog 1 (Drosophila), ZC2HC12A, nanos C2HC-type zinc finger 1
External IDs	OMIM: 608226 MGI: 2669254 HomoloGene: 131234 GeneCards: NANOS1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.11 Start 119,029,714 bp[1] End 119,033,730 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D3 Start 60,755,987 bp[2] End 60,759,914 bp[2]
Gene ontology Molecular function • zinc ion binding • metal ion binding • translation repressor activity • RNA binding • GO:0001948 protein binding Cellular component • cytoplasm • perinuclear region of cytoplasm Biological process • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • regulation of translation • cell migration • epithelial cell migration • negative regulation of translation • posttranscriptional regulation of gene expression • cerebellar neuron development • tissue homeostasis • regulation of cell growth Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	340719	332397
Ensembl	ENSG00000188613	ENSMUSG00000072437
UniProt	Q8WY41	Q80WY3
RefSeq (mRNA)	NM_199461 NM_001009553	NM_178421
RefSeq (protein)	NP_955631	NP_848508
Location (UCSC)	Chr 10: 119.03 – 119.03 Mb	Chr 19: 60.76 – 60.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000188613 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000072437 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Nanos homolog 1 (Drosophila)".

Further reading

• Bonnomet A, Polette M, Strumane K, Gilles C, Dalstein V, Kileztky C, Berx G, van Roy F, Birembaut P, Nawrocki-Raby B (June 2008). "The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression". Oncogene. 27 (26): 3692–9. doi:10.1038/sj.onc.1211035. PMID 18223680.
• Lu C, Xu M, Wang Y, Qin Y, Du G, Wu W, Han X, Ji C, Yang Y, Gu A, Xia Y, Song L, Wang S, Wang X (2013). "Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population". PLOS ONE. 8 (1): e53443. Bibcode:2013PLoSO...853443L. doi:10.1371/journal.pone.0053443. PMC 3540065. PMID 23320086.
• Kusz-Zamelczyk K, Sajek M, Spik A, Glazar R, Jędrzejczak P, Latos-Bieleńska A, Kotecki M, Pawelczyk L, Jaruzelska J (March 2013). "Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia". Journal of Medical Genetics. 50 (3): 187–93. doi:10.1136/jmedgenet-2012-101230. PMID 23315541.
• Ginter-Matuszewska B, Kusz K, Spik A, Grzeszkowiak D, Rembiszewska A, Kupryjanczyk J, Jaruzelska J (September 2011). "NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells". Histochemistry and Cell Biology. 136 (3): 279–87. doi:10.1007/s00418-011-0842-y. PMID 21800163.
• Strumane K, Bonnomet A, Stove C, Vandenbroucke R, Nawrocki-Raby B, Bruyneel E, Mareel M, Birembaut P, Berx G, van Roy F (October 2006). "E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion". Cancer Research. 66 (20): 10007–15. doi:10.1158/0008-5472.CAN-05-3096. PMID 17047063.
• Kurokawa H, Aoki Y, Nakamura S, Ebe Y, Kobayashi D, Tanaka M (April 2006). "Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes". Development, Growth & Differentiation. 48 (3): 209–21. doi:10.1111/j.1440-169X.2006.00858.x. PMID 16573738.
• Jaruzelska J, Kotecki M, Kusz K, Spik A, Firpo M, Reijo Pera RA (April 2003). "Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells". Development Genes and Evolution. 213 (3): 120–6. doi:10.1007/s00427-003-0303-2. PMID 12690449.
• Ginter-Matuszewska B, Spik A, Rembiszewska A, Koyias C, Kupryjanczyk J, Jaruzelska J (March 2009). "The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells". Molecular Human Reproduction. 15 (3): 173–9. doi:10.1093/molehr/gap004. PMID 19168546.
• Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (July 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience. 3 (7): 661–9. doi:10.1038/76615. hdl:1842/742. PMID 10862698.