NAB1

NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene.[5][6][7][8]

NAB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YUF
Identifiers
Aliases	NAB1, NGFI-A binding protein 1
External IDs	OMIM: 600800 MGI: 107564 HomoloGene: 4352 GeneCards: NAB1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.2 Start 190,646,746 bp[1] End 190,692,766 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.1|1 26.99 cM Start 52,457,294 bp[2] End 52,500,679 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transcription factor binding • GO:0001104 transcription cofactor activity Cellular component • cell nucleus Biological process • Schwann cell differentiation • myelination • endochondral ossification • regulation of epidermis development • transcription, DNA-templated • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4664	17936
Ensembl	ENSG00000138386	ENSMUSG00000002881
UniProt	Q13506	Q61122
RefSeq (mRNA)	NM_005966 NM_001321312 NM_001321313 NM_001321314 NM_001321315	NM_008667
RefSeq (protein)	NP_001308241 NP_001308242 NP_001308243 NP_001308244 NP_005957	NP_032693
Location (UCSC)	Chr 2: 190.65 – 190.69 Mb	Chr 1: 52.46 – 52.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

NAB1 has been shown to interact with Zif268.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000138386 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002881 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Russo MW, Sevetson BR, Milbrandt J (Aug 1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription". Proc Natl Acad Sci U S A. 92 (15): 6873–7. Bibcode:1995PNAS...92.6873R. doi:10.1073/pnas.92.15.6873. PMC 41432. PMID 7624335.
6. Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. doi:10.1128/MCB.16.7.3545. PMC 231349. PMID 8668170.
7. Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J (Jan 1998). "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain". Mol Cell Biol. 18 (1): 512–24. doi:10.1128/MCB.18.1.512. PMC 115883. PMID 9418898.
8. "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Thiel G, Kaufmann K, Magin A, et al. (2000). "The human transcriptional repressor protein NAB1: expression and biological activity". Biochim. Biophys. Acta. 1493 (3): 289–301. doi:10.1016/s0167-4781(00)00207-4. PMID 11018254.
• Qiu FH, Devchand PR, Wada K, Serhan CN (2002). "Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils". FASEB J. 15 (14): 2736–8. doi:10.1096/fj.01-0576fje. PMID 11687510.
• Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics. 4 (1): 37–41. doi:10.1007/s10048-001-0124-2. PMID 12030330.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.