Myxobacteria

The myxobacteria ("slime bacteria") are a group of bacteria that predominantly live in the soil and feed on insoluble organic substances. The myxobacteria have very large genomes relative to other bacteria, e.g. 9–10 million nucleotides except for Anaeromyxobacter[1] and Vulgatibacter.[2] One species of myxobacteria, Minicystis rosea,[3] has the largest known bacterial genome with over 16 million nucleotides. The second largest is another myxobacteria Sorangium cellulosum.[4][5] Myxobacteria are included among the delta group of proteobacteria, a large taxon of Gram-negative forms.

Not to be confused with Slime mold.

Myxobacteria
Myxococcus xanthus
Scientific classification
Kingdom:
Bacteria
Phylum:
Proteobacteria
Class:
Deltaproteobacteria
Order:
Myxococcales

Myxobacteria can move by gliding.[6] They typically travel in swarms (also known as wolf packs), containing many cells kept together by intercellular molecular signals. Individuals benefit from aggregation as it allows accumulation of the extracellular enzymes that are used to digest food; this in turn increases feeding efficiency. Myxobacteria produce a number of biomedically and industrially useful chemicals, such as antibiotics, and export those chemicals outside the cell.[7]

Life cycle

When nutrients are scarce, myxobacterial cells aggregate into fruiting bodies (not to be confused with those in fungi), a process long-thought to be mediated by chemotaxis but now considered to be a function of a form of contact-mediated signaling.[8][9] These fruiting bodies can take different shapes and colors, depending on the species. Within the fruiting bodies, cells begin as rod-shaped vegetative cells, and develop into rounded myxospores with thick cell walls. These myxospores, analogous to spores in other organisms, are more likely to survive until nutrients are more plentiful. The fruiting process is thought to benefit myxobacteria by ensuring that cell growth is resumed with a group (swarm) of myxobacteria, rather than as isolated cells. Similar life cycles have developed among certain amoebae, called cellular slime molds.

At a molecular level, initiation of fruiting body development in Myxococcus xanthus is regulated by Pxr sRNA.[10][11]

Myxobacteria such as Myxococcus xanthus and Stigmatella aurantiaca are used as model organisms for the study of development.

Various myxobacterial species as sketched by Roland Thaxter in 1892: Chondromyces crocatus (figs. 1–11), Stigmatella aurantiaca (figs. 12–19 and 25-28), Melittangium lichenicola (figs. 20–23), Archangium gephyra (fig. 24), Myxococcus coralloides (figs. 29-33), Polyangium vitellinum (figs. 34-36), and Myxococcus fulvus (figs. 37-41). Thaxter was the first taxonomist to recognize the bacterial nature of the myxobacteria. Previously, they had been misclassified as members of the fungi imperfecti.


Clinical use

Metabolites secreted by Sorangium cellulosum known as epothilones have been noted to have antineoplastic activity. This has led to the development of analogs which mimic its activity. One such analog, known as Ixabepilone is a U.S. Food and Drug Administration approved chemotherapy agent for the treatment of metastatic breast cancer.[12]

Myxobacteria are also known to produce gephyronic acid, an inhibitor of eukaryotic protein synthesis and a potential agent for cancer chemotherapy.[13]


gollark: You might just need to use a smaller model.
gollark: For more than a minute.
gollark: Int8 apparently causes it to just output random noise and I never got round to trying quantisation aware training for it.
gollark: It's quite strange that apparently BERT can be statically quantized without any extra training and retains decent accuracy but GPT-Neo emits nonsense going through the same process.
gollark: I was looking into quantization-aware training a while ago, but on the 125M model, and running that for a bit made it produce English-looking nonsense instead of random noise.

References
  1. Thomas SH, Wagner RD, Arakaki AK, Skolnick J, Kirby JR, Shimkets LJ, Sanford RA, Löffler FE (May 2008). "The mosaic genome of Anaeromyxobacter dehalogenans strain 2CP-C suggests an aerobic common ancestor to the delta-proteobacteria". PLoS ONE. 3 (5): e2103. doi:10.1371/journal.pone.0002103. PMC 2330069. PMID 18461135.
  2. "Vulgatibacter incomptus strain DSM 27710, complete genome". 2015-08-19. Cite journal requires |journal= (help)
  3. "Minicystis rosea strain DSM 24000, complete genome". 2017-01-04. Cite journal requires |journal= (help)
  4. Schneiker S, Perlova O, Kaiser O, Gerth K, Alici A, Altmeyer MO, et al. (November 2007). "Complete genome sequence of the myxobacterium, Sorangium cellulosum". Nat. Biotechnol. 25 (11): 1281–9. doi:10.1038/nbt1354. PMID 17965706.
  5. Land M, Hauser L, Jun SR, Nookaew I, Leuze MR, Ahn TH, Karpinets T, Lund O, Kora G, Wassenaar T, Poudel S, Ussery DW (March 2015). "Insights from 20 years of bacterial genome sequencing". Funct. Integr. Genomics. 15 (2): 141–61. doi:10.1007/s10142-015-0433-4. PMC 4361730. PMID 25722247.
  6. Mauriello EM, Mignot T, Yang Z, Zusman DR (June 2010). "Gliding motility revisited: how do the myxobacteria move without flagella?". Microbiol. Mol. Biol. Rev. 74 (2): 229–49. doi:10.1128/MMBR.00043-09. PMC 2884410. PMID 20508248.
  7. Reichenbach H (September 2001). "Myxobacteria, producers of novel bioactive substances". J. Ind. Microbiol. Biotechnol. 27 (3): 149–56. doi:10.1038/sj.jim.7000025. PMID 11780785.
  8. Kiskowski MA, Jiang Y, Alber MS (December 2004). "Role of streams in myxobacteria aggregate formation". Phys Biol. 1 (3–4): 173–83. doi:10.1088/1478-3967/1/3/005. PMID 16204837.
  9. Sozinova O, Jiang Y, Kaiser D, Alber M (August 2005). "A three-dimensional model of myxobacterial aggregation by contact-mediated interactions". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11308–12. doi:10.1073/pnas.0504259102. PMC 1183571. PMID 16061806.
  10. Yu YT, Yuan X, Velicer GJ (May 2010). "Adaptive evolution of an sRNA that controls Myxococcus development". Science. 328 (5981): 993. doi:10.1126/science.1187200. PMC 3027070. PMID 20489016.
  11. Fiegna F, Yu YT, Kadam SV, Velicer GJ (May 2006). "Evolution of an obligate social cheater to a superior cooperator". Nature. 441 (7091): 310–4. doi:10.1038/nature04677. PMID 16710413.
  12. "FDA Approval for Ixabepilone". National Cancer Institute.
  13. Sasse F, Steinmetz H, Höfle G, Reichenbach H (January 1995). "Gephyronic acid, a novel inhibitor of eukaryotic protein synthesis from Archangium gephyra (myxobacteria). Production, isolation, physico-chemical and biological properties, and mechanism of action". J. Antibiot. 48 (1): 21–5. doi:10.7164/antibiotics.48.21. PMID 7868385.
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