Myrotoxin B

Myrotoxin B
Identifiers
CAS Number	99486-49-4 ;
3D model (JSmol)	Interactive image;
PubChem CID	6540635;
UNII	1PX13P7HGK ;
	SMILES CC1=C[C@]2([H])[C@]([C@@](C)3[C@]4(CO4)[C@@]([H])(C[C@H]3OC5=O)O2)(CO[C@]([C@@H](O7)[C@]([C@H]/6O)7CCOC6=C/C/C=C\5)=O)C[C@@H]1OC(C)=O;
Properties
Chemical formula	C29H34O11
Molar mass	558.580 g·mol−1
Melting point	195 to 197 °C (383 to 387 °F; 468 to 470 K)[1]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Myrotoxin B is a macrocyclic trichothecene first isolated in 1985.[1] It was tested on Swiss mice and found to be very toxic, though not the most toxic of the three toxins that were tested at that time.[2] It has also been isolated from Myrothecium roridum, a pathogen leaf spot that affects mulberry, though it is unknown if it is used as a pathotoxin.[3]

References

Jarvis, B. B.; Lee, Y.-W.; Cömezoḡlu, F. T.; Cömezoḡlu, S. N.; Bean, G. A. (1985). "Myrotoxins: a new class of macrocyclic trichothecenes". Tetrahedron Letters. 26 (40): 4859–62. doi:10.1016/S0040-4039(00)94970-0.
Schiefer, H. B.; Hancock, D. S.; Jarvis, B. B. (1989). "Toxicology of Novel Macrocyclic Trichothecenes, Baccharinoid B4, Myrotoxin B, and Roritoxin B". Zentralblatt für Veterinärmedizin. Reihe A. 36 (2): 152–60. ISSN 0514-7158. PMID 2501953.
Murakami, R.; Shirata, A. (2005). "Myrotoxin B Detection from Mulberry Leaves Infected with Myrothecium roridum, cause Myrothecium Leaf Spot of Mulberry, and Possible Roles in Pathogenicity" (pdf). Japanese Journal of Phytopathology. 71 (2): 91–100. doi:10.3186/jjphytopath.71.91.

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[jarvis-1] Jarvis, B. B.; Lee, Y.-W.; Cömezoḡlu, F. T.; Cömezoḡlu, S. N.; Bean, G. A. (1985). "Myrotoxins: a new class of macrocyclic trichothecenes". Tetrahedron Letters. 26 (40): 4859–62. doi:10.1016/S0040-4039(00)94970-0.

[2] Schiefer, H. B.; Hancock, D. S.; Jarvis, B. B. (1989). "Toxicology of Novel Macrocyclic Trichothecenes, Baccharinoid B4, Myrotoxin B, and Roritoxin B". Zentralblatt für Veterinärmedizin. Reihe A. 36 (2): 152–60. ISSN 0514-7158. PMID 2501953.

[3] Murakami, R.; Shirata, A. (2005). "Myrotoxin B Detection from Mulberry Leaves Infected with Myrothecium roridum, cause Myrothecium Leaf Spot of Mulberry, and Possible Roles in Pathogenicity" (pdf). Japanese Journal of Phytopathology. 71 (2): 91–100. doi:10.3186/jjphytopath.71.91.