Mitochondrial ribosomal protein l13

Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene. [4]

MRPL13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL13, L13, L13A, L13mt, RPL13, RPML13, mitochondrial ribosomal protein L13
External IDs	OMIM: 610200 MGI: 2137218 HomoloGene: 90894 GeneCards: MRPL13
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.12 Start 120,380,761 bp[1] End 120,445,402 bp[1]
Gene ontology Molecular function • structural constituent of ribosome • GO:0001948 protein binding • mRNA binding • RNA binding Cellular component • mitochondrial inner membrane • ribosome • mitochondrial ribosome • mitochondrion • mitochondrial large ribosomal subunit Biological process • mitochondrial translational elongation • mitochondrial translational termination • protein biosynthesis • negative regulation of translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	28998	68537
Ensembl	ENSG00000172172	n/a
UniProt	Q9BYD1	Q9D1P0
RefSeq (mRNA)	NM_014078	NM_026759
RefSeq (protein)	NP_054797	NP_081035
Location (UCSC)	Chr 8: 120.38 – 120.45 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

References

1. GRCh38: Ensembl release 89: ENSG00000172172 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Mitochondrial ribosomal protein L13". Retrieved 2017-07-05.

Further reading

• Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, Fox PL (2008). "DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression". Mol. Cell. 32 (3): 371–82. doi:10.1016/j.molcel.2008.09.019. PMC 2644327. PMID 18995835.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.