MicL sRNA

MicL sRNA
	Predicted secondary structure and sequence conservation of MicL small RNA
Identifiers
Rfam	RF02654
Other data
Domain(s)	Bacteria
GO	0030371
SO	0000370
PDB structures	PDBe

MicL RNA (mRNA-interfering complementary RNA regulator of Lpp) is a σ ^E transcription factor-dependent small non-coding RNA. It was discovered in E. coli. Together with MicA and RybB sRNAs, MicL sRNA down-regulates the synthesis of abundant outer membrane proteins in response to stress. MicL specifically targets mRNA of lipoprotein Lpp, preventing its translation.[1]

References

Guo MS, Updegrove TB, Gogol EB, Shabalina SA, Gross CA, Storz G (July 2014). "MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein". Genes & Development. 28 (14): 1620–1634. doi:10.1101/gad.243485.114. PMC 4102768. PMID 25030700.

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[1] Guo MS, Updegrove TB, Gogol EB, Shabalina SA, Gross CA, Storz G (July 2014). "MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein". Genes & Development. 28 (14): 1620–1634. doi:10.1101/gad.243485.114. PMC 4102768. PMID 25030700.