Metallochaperones

Metallochaperones are a distinct class of molecular chaperone that facilitate intracellular transport of metal ions to metalloenzymes and metalloproteins in cells through protein-protein interactions.[1] The proteins ensure that the correct metal ion is acquired by its corresponding metalloenzyme. Metallochaperones are essential to the proper functioning of cells, playing a vital role in a large number of biological processes including respiration, photosynthesis, neurotransmission.[2]

Prior to the discovery of metallochaperones in the late 1990s, biologists believed that metal ions freely diffused within cells without the aid of auxiliary proteins.

References
  1. Rosenzweig, Amy C (2002-06-01). "Metallochaperones: Bind and Deliver". Chemistry & Biology. 9 (6): 673–677. doi:10.1016/S1074-5521(02)00156-4. ISSN 1074-5521.
  2. Sekhon, Bhupinder Singh (2010-05-01). "Metallochaperones - an Overview". Current Chemical Biology. Retrieved 2019-01-21.


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