Maria Natasha Rajah

Maria Natashini "Natasha" Rajah is a Canadian neuroscientist who is Professor at the Department of Psychiatry, McGill University, and Director of the Douglas Brain Imaging Centre. She is particularly interested in memory, ageing and dementia. Her research uses functional magnetic resonance imaging to establish how biological variables impact the neural networks responsible for memory creation and retrieval.

Maria Natasha Rajah
Alma materUniversity of Toronto
Scientific career
InstitutionsMcGill University
University of California, Berkeley
WebsiteRajah laboratory

Early life and education

Rajah studied psychology at the University of Toronto – St. George Campus and obtained her bachelor's degree, specialising in psychology in 1996. During this time she worked with Randy McIntosh for her undergraduate honours thesis which used O15 positron emission tomography (PET) to study associative learning in young adults. She continued to work with McIntosh for her postgraduate research at University of Toronto and the Rotman Research Institute.  She earned her master's degree in 1998 and her doctoral degree in 2003. Her research involved the use of neuroimaging methods to understand ageing and memory.[1] She focused on studying age-related differences in the function of the prefrontal cortex. She moved to the University of California, Berkeley for her postdoctoral research, where she continued her work on ageing and the function of the prefrontal cortex with Mark D'Esposito.[2]

Research and career

In 2005 Rajah was appointed to Douglas Mental Health University Institute and the Department of Psychiatry, McGill University, as an Assistant Professor.[1] She was awarded a Canadian Institutes of Health Research New Investigator Award in 2007.[1]

Her research involves the use of fMRI to understand the way biological and demographic variables impact the neural networks that mediate memory formation and retrieval across the adult lifespan.[3] This includes studying how biological sex, stress and lifestyle factors influence brain function in healthy ageing and in adults at risk of late-onset Alzheimer's disease.[3] She uses complementary image analysis technique (including multivariate, univariate and connectivity analysis) to answer her research questions.[4]

Most recently, Rajah has begun to study memory decline in healthy middle-aged adults over the age of 40.[5] She designed an experiment that showed participants a series of faces, and subsequently asked them to identify where and when the image of a particular face appeared on a screen. During the study Rajah monitored the participant's brains using MRI.[5] She showed that memory decline started in early midlife and was linked to age-related differences in occipital-temporal and ventrolateral prefrontal cortex function.  Additional memory decline in older adults was linked to more differences in lateral prefrontal, parietal, and medial temporal function. Rajah concluded that age-related decline in memory may be related to age differences in what middle-aged and older adults consider important information, compared to young adults.[5][6] She is now investigating sex differences and the effect of menopause on brain function related to memory.[6]

In 2011, Rajah was appointed Director of the Douglas Mental Health University Institute Brain Imaging Centre.[3] The centre contains a 3T Siemens Prisma-Fit Trio MRI scanner that can be used for human imaging, as well as 7T Bruker MRI Scanner for imaging small animals.[1] In 2017 Rajah joined the Canadian Open Neuroscience Platform, which shares brain data between Canadian researchers.[7] Rajah was tenured at the level of Associate Professor, Department of Psychiatry, McGill University in 2016 and was promoted to Full Professor in 2019. She is an Associate Member at the Department of Psychology, McGill University; is a member of the Centre for Research on Brain, Language and Music (CRBLM), Women in Cognitive Science Canada (WiCSC), Memory Disorder's Research Society (MDRS), and the International Society of Behavioral Neuroscience (ISBN).

Awards and honours
  • 2007 Canadian Institute of Health Research (CIHR), New Investigator Salary Award
  • 2007 Fonds de la Recherche en Santé Québec (FRSQ), Junior 1 Salary Award
  • 2013 John R. & Clara M. Fraser Memorial Award[8]
  • 2014 Fonds de Recherche du Québec - Santé (FRQ-S), Junior 2 Salary Award
  • 2019 Women in Cognitive Science Canada Mentorship Award
  • 2019 McGill University Haile T. Debas Prize[9]

Selected publications
  • Rajah, M Natasha; D'Esposito, Mark (2005). "Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory". Brain. 128 (9): 1964–1983. doi:10.1093/brain/awh608. PMID 16049041.
  • McIntosh, Anthony Randal; Rajah, M Natasha; Lobaugh, Nancy J (2005). "Interactions of prefrontal cortex in relation to awareness in sensory learning". Science. 284 (5419): 1531–1533. doi:10.1126/science.284.5419.1531. PMID 10348741.
  • Grady, Cheryl; Rajah, M Natasha; Craik, Fergus IM (1998). "Neural correlates of the episodic encoding of pictures and words". Proceedings of the National Academy of Sciences. 95: Neural correlates of the episodic encoding of pictures and words.

She is the Editor-in-Chief for Ageing, Neuropsychology and Cognition and a Senior Editor for Brain Research.[1]

gollark: ~~just run `switchcraft.tps()` in a loop with `os.queueEvent"" os.pullEvent ""`~~
gollark: Don't?
gollark: The easiest way to measure TPS is just to run horribly intensive tasks on the Potatodatacentre so that it's stuck at 1 or so.
gollark: We have one in Chorus City.
gollark: It just tracks the speed difference between computer time (from `sleep(1)`) and UTC (from `os.epoch "utc"`), which gets it to within a few... TPS units generally.

References
  1. "Maria Natasha Rajah". www.journals.elsevier.com. Retrieved 2019-10-13.
  2. Rajah, M. Natasha; D'Esposito, Mark (2005-09-01). "Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory". Brain. 128 (9): 1964–1983. doi:10.1093/brain/awh608. ISSN 0006-8950. PMID 16049041.
  3. "Maria Natasha Rajah | The Douglas Research Centre". douglas.research.mcgill.ca. Retrieved 2019-10-13.
  4. "Maria Natasha Rajah". CRBLM. Retrieved 2019-10-13.
  5. "Is it normal to start forgetting stuff after you turn 40?". Futurity. 2016-07-13. Retrieved 2019-10-13.
  6. Harrison, Pam. "Midlife Memory Lapses May Be Normal Part of Aging". WebMD. Retrieved 2019-10-13.
  7. Neumann, Karl (2018-03-27). "Neuroscience gets even brainier with open access science". The McGill Tribune. Retrieved 2019-10-13.
  8. "Awards and Distinctions - Douglas Mental Health University Institute". www.douglas.qc.ca. Retrieved 2019-10-13.
  9. "Maria Natasha Rajah, 2019 recipient of the Haile T. Debas Prize". McGill . University. Retrieved 2019-10-13.
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