Manoj Kumar Jaiswal

Manoj Kumar Jaiswal (Hindi: मनोज कुमार जायसवाल) is an Indian neuroscientist.[1] He is the full-time faculty (Instructor) in the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai.[2]

Manoj Kumar Jaiswal
Manoj Kumar Jaiswal at MIT, Boston 2009
Alma materMassachusetts Institute of Technology, Center for Neuroscience and Regenerative Medicine, Columbia University, Georg-August University
Known forCalcium and Mitochondrial Signalling in Motor Neuron Disease
Scientific career
FieldsNeuroscience
InstitutionsIcahn School of Medicine at Mount Sinai
ThesisOptical Analysis of Ca2+i and Mitochondrial Signaling Pathways: Implications for the Selective Vulnerability of Motoneurons in Amyotrophic Lateral Sclerosis (ALS) (2008)
Doctoral advisorBernhard U. Keller

Early life and education

Jaiswal was born in Varanasi (Hindustani pronunciation: [ʋaːˈraːɳəsi], also known as Benares, Banaras (Banāras [bəˈnaːrəs], or Kashi (Kāśī [ˈkaːʃi], a major religious hub in India and holiest of the seven sacred cities (Sapta Puri) in Hinduism and Jainism. He became interested in Biology at a young age and began doing research in the field as an undergraduate student.[3][4]

Career

In Jan 2008 he received his Ph.D. degree from the University of Göttingen in Germany. He was a Postdoctoral Fellow in 2009 at the Massachusetts Institute of Technology in Cambridge, Massachusetts. From 2010 to 2015 he was a Research Fellow I Junior Scientist at the Center of Neuroscience and Regenerative Medicine, in Bethesda, Maryland. From 2015 to 2017 he was a Scientist at the New York State Psychiatric Institute/ Columbia University Department of Psychiatry, in New York City, New York. In 2017, he became the full-time faculty (Instructor) at Icahn School of Medicine at Mount Sinai in New York City, New York.[2]

Jaiswal studies the critical role of Cu, Zn superoxide dismutase (SOD1), typical for familial ALS, in the impairment of [Ca2+]mito handling and perturbation of Ca2+ homeostasis in SOD1G93A mice and cell culture models of ALS. These finding, reported in Pharmacology [5] and Neuroscience Journal.[6][7] Jaiswal has also studied molecular mechanisms of Traumatic Brain Injury (TBI) using 2-photon in-vivo imaging and 3-D microscopy at CNRM/NIH-DoD center. He developed a minimally invasive in-vivo 2-photon imaging method and established SCALEA2/CLARITY tissue clearing techniques for intact volumetric 3-D imaging of optically cleared transparent mouse and human brains. As a Research Scientist in the Department of Psychiatry at the Columbia University Medical Center in New York, he focused on studying adult neurogenesis in the brains of patients with major depression and other psychiatric disorders. His lab work is conducted on mice, induced pluripotent stem cells (iPSC) and Human postmortem tissue. Jaiswal also has an avid interest in science communications as well as science and society.

Jaiswal's recent projects included studies related to neurodegenration in ALS [8][9] Brain Injury [10] Epigenetics [11] and psychiatric disorders.[12][13] Hyperexcitability is considered to be a hallmark of ALS, and it has been suggested that the ALS-associated hyperexcitability may stem from altered function of the neuronal glutamate receptors due to inefficient RNA editing of one of the receptor's subunits. Immediate major focus of his work will test this hypothesis using (1) autopsied tissues obtained from brain and spinal cord of ALS patients and (2) motoneurons differentiated from human induced pluripotent stem cells (hiPSC) derived from ALS patients.[14]

Selected publications

Books
  • Jaiswal, Manoj K. (2017), The role of mitochondria, oxidative stress and altered calcium homeostasis in Amyotrophic Lateral Sclerosis: from current developments in the laboratory to clinical treatments, Switzerland: Frontiers Media SA, ISBN 9782889451463.
  • Jaiswal, Manoj K. (2012), Motoneuron specific calcium dysregulation and perturbed cellular calcium homestasis in amyotrophic lateral sclerosis: recent advances gained from genetically modified animals and cell culture models. In Motor Neuron Diseases: Causes, Classification and Treatments. In Bradley J. Turner and Julie B. Atkin, New York: Nova Publishers, ISBN 978-1-61470-101-9.
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References
  1. "Dr. Manoj Kumar Jaiswal Google Scholar Profile".
  2. "Dr. Manoj Kumar Jaiswal Icahn School of Medicine at Mount Sinai Faculty profile".
  3. Saxena, A; Varadwaj, P; Singh, S; Jaiswal, M; et al. "Phylogentetic analysis of Mycobacterium leprae genome for identification of novel drug targets" (PDF). Indian Journal of Biotechnology. 5: 58–61.
  4. Jaiswal, M. "DipteraWG: A Relational Database of Dipteran Biodiversity of Western Ghat Hot Spots". Bioinformatics Trends. 1: 1–26.
  5. Jaiswal, MK; Keller, BU (2009). "Cu/Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of mitochondria and perturbs Ca2+ homeostasis in SOD1G93A mice". Mol Pharmacol. 75 (3): 478–89. doi:10.1124/mol.108.050831. PMID 19060114.
  6. Jaiswal, MK; Zech, WD; Goos, M; et al. (2009). "Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease". BMC Neurosci. 10: 64. doi:10.1186/1471-2202-10-64. PMC 2716351. PMID 19545440.
  7. Goos, M; Zech, WD; Jaiswal, MK; et al. (2007). "Expression of a Cu, Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury". BMC Infectious Diseases. 7: 131. doi:10.1186/1471-2334-7-131. PMC 2211486. PMID 17997855.
  8. Jaiswal, MK (2016). "Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca2+ Signaling in Amyotrophic Lateral Sclerosis". Front Cell Neurosci. 10: 295. doi:10.3389/fncel.2016.00295. PMC 5216043. PMID 28111541.
  9. Jaiswal, MK (2018). "Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs". Med Res Rev. 38 (2): 733–748. doi:10.1002/med.21528. PMID 30101496.
  10. Jaiswal, MK (2015). "Toward a High-Resolution Neuroimaging Biomarker for Mild Traumatic Brain Injury: From Bench to Bedside". Front Neurol. 6: 148. doi:10.3389/fneur.2015.00148. PMC 4492079. PMID 26217296.
  11. Ranjana, V; Xu, X; Jaiswal, MK; et al. (2011). "In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components". Toxicology and Applied Pharmacology. 253 (3): 178–187. doi:10.1016/j.taap.2011.04.002. PMID 21513724.
  12. Aizenstein, HJ; Baskys, A; Boldrini, M; Butters, MA; Diniz, BS; Jaiswal, MK; Jellinger, KA; Kruglov, LS; Meshandin, IA; Mijajlovic, MD; Niklewski, G; Pospos, S; Raju, K; Richter, K; Steffens, DC; Taylor, WD; Tene, O (2016). "Vascular depression consensus report - a critical update". BMC Med. 14 (1): 161. doi:10.1186/s12916-016-0720-5. PMC 5093970. PMID 27806704.
  13. Seki, K; Yoshida, S; Jaiswal, MK (2018). "Molecular mechanism of noradrenaline during the stress-induced major depressive disorder". Neural Regen Res. 13 (7): 1159–1169. doi:10.4103/1673-5374.235019. PMC 6065220. PMID 30028316.
  14. Jaiswal, MK (2017). "Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease". Neural Regen Res. 12 (5): 723–736. doi:10.4103/1673-5374.206635. PMC 5461603. PMID 28616022.
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