Malotilate

Malotilate (INN) is a drug used in the treatment of liver disease. It has been shown to facilitate liver regeneration in rats.[1]

Malotilate

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name diisopropyl 1,3-dithiol-2-ylidenemalonate
CAS Number	59937-28-9^N
PubChem CID	4006
ChemSpider	3866^N
UNII	RV59PND975
ChEMBL	ChEMBL1697754^N
CompTox Dashboard (EPA)	DTXSID7046463
ECHA InfoCard	100.056.334
Chemical and physical data
Formula	C12H16O4S2
Molar mass	288.38 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C
InChI InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3^N Key:YPIQVCUJEKAZCP-UHFFFAOYSA-N^N
^NY (what is this?)  (verify)

References

1. Niwano et al, Acceleration of Liver Regeneration by Malotilate in Partially Hepatectomized Rats

• Bührer M, Le Cotonnec JY, Wermeille M, Bircher J (1986). "Treatment of liver disease with malotilate. A pharmacokinetic and pharmacodynamic phase II study in cirrhosis". Eur. J. Clin. Pharmacol. 30 (4): 407–16. doi:10.1007/BF00607952. PMID 3743616.
• Siegers CP, Pauli V, Korb G, Younes M (August 1986). "Hepatoprotection by malotilate against carbon tetrachloride-alcohol-induced liver fibrosis". Agents Actions. 18 (5–6): 600–3. doi:10.1007/BF01964970. PMID 3766314.
• Younes M, Siegers CP (May 1985). "Effect of malotilate on paracetamol-induced hepatotoxicity". Toxicol. Lett. 25 (2): 143–6. doi:10.1016/0378-4274(85)90074-8. PMID 4002245.