Addressin

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.[3][4][5]

MADCAM1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1
External IDsOMIM: 102670 GeneCards: MADCAM1
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start489,176 bp[1]
End505,343 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8174

n/a

Ensembl

ENSG00000099866

n/a

UniProt

Q13477

n/a

RefSeq (mRNA)

NM_130762
NM_130760

n/a

RefSeq (protein)

NP_570116
NP_570118

n/a

Location (UCSC)Chr 19: 0.49 – 0.51 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Addressin is an extracellular protein of the endothelium of venules.

Addressins are the ligands to the homing receptors of lymphocytes.[6] The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. They carry carbohydrates in order to be recognized by L-selectin.

Function

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.[3]

In terms of migration, MADCAM is selectively expressed on mucosal endothelial cells, driving memory T-cell re-circulation through mucosal tissues. In contrast, and indeed the main difference between the two molecules, ICAM molecules are involved with naive T-cell re-circulation. Whereas MADCAM is selectively expressed, ICAM is broadly expressed on inflamed endothelium.

gollark: ++help experimental_qa
gollark: I mean, at the very least it's documented in the code, with no comments.
gollark: Yes. This is documented somewhere maybe.
gollark: You just feed it some context, and the question, and then it something something matrix multiplication, and then it does postprocessing to turn the output into a span in the original text, and answers come out.
gollark: It doesn't do training. That would be *unusably* slow.

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000099866 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1".
  4. Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". J. Immunol. 156 (8): 2851–7. PMID 8609404.
  5. Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, Ni J, Carter KC, Spurr N, Choo KH, Krissansen GW (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics. 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097.
  6. Addressin Archived 2016-12-01 at the Wayback Machine at eMedicine Dictionary

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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