MXRA5

Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.[3]

MXRA5
Identifiers
Aliases	MXRA5, matrix remodeling associated 5
External IDs	OMIM: 300938 HomoloGene: 56704 GeneCards: MXRA5
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.33 Start 3,308,565 bp[1] End 3,346,652 bp[1]
Gene ontology Molecular function • molecular function • extracellular matrix structural constituent Cellular component • extracellular exosome • extracellular region • collagen-containing extracellular matrix Biological process • response to transforming growth factor beta Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25878	n/a
Ensembl	ENSG00000101825	n/a
UniProt	Q9NR99	n/a
RefSeq (mRNA)	NM_015419	n/a
RefSeq (protein)	NP_056234	n/a
Location (UCSC)	Chr X: 3.31 – 3.35 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y.[3]

Clinical relevance

Mutations in this gene have been seen frequently mutated in cases of non-small cell lung carcinoma.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000101825 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Matrix-remodelling associated 5". Retrieved 2012-07-24.
4. Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M (Sep 2012). "Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients". Carcinogenesis. 33 (9): 1797–805. doi:10.1093/carcin/bgs210. PMC 3514907. PMID 22696596.

Further reading

• Chondrogianni N, de C M Simoes D, Franceschi C, Gonos ES (2004). "Cloning of differentially expressed genes in skin fibroblasts from centenarians". Biogerontology. 5 (6): 401–9. doi:10.1007/s10522-004-3188-1. PMID 15609104.
• Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (Jul 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Zou TT, Selaru FM, Xu Y, Shustova V, Yin J, Mori Y, Shibata D, Sato F, Wang S, Olaru A, Deacu E, Liu TC, Abraham JM, Meltzer SJ (Jul 2002). "Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon". Oncogene. 21 (31): 4855–62. doi:10.1038/sj.onc.1205613. PMID 12101425.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.