MRCL3

Myosin regulatory light chain 12A is a protein that in humans is encoded by the MYL12A gene.[4][5]

MYL12A
Identifiers
Aliases	MYL12A, HEL-S-24, MLCB, MRCL3, MRLC3, MYL2B, MLC-2B, myosin light chain 12A
External IDs	MGI: 107494 HomoloGene: 23407 GeneCards: MYL12A
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.31 Start 3,247,481 bp[1] End 3,256,236 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • GO:0001948 protein binding • metal ion binding • myosin heavy chain binding Cellular component • cytosol • extracellular exosome • myosin complex • myosin II complex • apical part of cell • Z disc • brush border • stress fiber • cell cortex region Biological process • ephrin receptor signaling pathway • muscle contraction • platelet aggregation • regulation of cell shape Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10627	67938
Ensembl	ENSG00000101608	n/a
UniProt	P19105 O14950	Q3THE2
RefSeq (mRNA)	NM_001303047 NM_001303048 NM_001303049 NM_006471	NM_023402
RefSeq (protein)	NP_001289976 NP_001289977 NP_001289978 NP_006462 NP_001138416 NP_001138417 NP_291024 NP_001289976 NP_001289977 NP_001289978 NP_006462	NP_075891
Location (UCSC)	Chr 18: 3.25 – 3.26 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000101608 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Grant JW, Zhong RQ, McEwen PM, Church SL (Nov 1990). "Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA". Nucleic Acids Res. 18 (19): 5892. doi:10.1093/nar/18.19.5892. PMC 332341. PMID 2216787.
5. "Entrez Gene: MRCL3 myosin regulatory light chain MRCL3".

Further reading

• Kobayashi K, Xin Y, Ymer SI, et al. (2007). "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells". Brain Res. 1170: 129–39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Iwasaki T, Murata-Hori M, Ishitobi S, Hosoya H (2002). "Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells". Cell Struct. Funct. 26 (6): 677–83. doi:10.1247/csf.26.677. PMID 11942626.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.