MPP2

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.[5][6]

MPP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E7K
Identifiers
Aliases	MPP2, DLG2, membrane palmitoylated protein 2
External IDs	OMIM: 600723 MGI: 1858257 HomoloGene: 3920 GeneCards: MPP2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,875,357 bp[1] End 43,909,711 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 65.48 cM Start 102,057,015 bp[2] End 102,088,515 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • guanylate kinase activity • GO:0001948 protein binding Cellular component • integral component of plasma membrane • GO:0097483, GO:0097481 postsynaptic density • dendrite membrane • dendritic spine • dendritic shaft • cytoplasm • cytoskeleton • cell membrane • membrane • dendrite • dendritic spine membrane • cell projection Biological process • signal transduction • GMP metabolic process • GDP metabolic process • protein homooligomerization • excitatory postsynaptic potential • long-term synaptic potentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4355	50997
Ensembl	ENSG00000108852	ENSMUSG00000017314
UniProt	Q14168	Q9WV34
RefSeq (mRNA)	NM_001278370 NM_001278371 NM_001278372 NM_001278373 NM_001278374 NM_001278375 NM_001278376 NM_001278381 NM_005374	NM_016695 NM_001356324
RefSeq (protein)	NP_001265299 NP_001265300 NP_001265301 NP_001265302 NP_001265303 NP_001265304 NP_001265305 NP_001265310 NP_005365	NP_057904 NP_001343253
Location (UCSC)	Chr 17: 43.88 – 43.91 Mb	Chr 11: 102.06 – 102.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000108852 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017314 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995). "A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A". Genomics. 28 (1): 25–31. doi:10.1006/geno.1995.1101. PMID 7590743.
6. "Entrez Gene: MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Smith SA, Holik P, Stevens J, et al. (1997). "Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21". Genomics. 31 (2): 145–50. doi:10.1006/geno.1996.0025. PMID 8824795.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wierstra I, Alves J (2006). "Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains". Biol. Chem. 387 (7): 963–76. doi:10.1515/BC.2006.120. PMID 16913846.