MPHOSPH8

M-phase phosphoprotein 8 is an enzyme that in humans is encoded by the MPHOSPH8 gene.[5][6]

MPHOSPH8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LWE, 3QO2, 3R93, 3SVM
Identifiers
Aliases	MPHOSPH8, HSMPP8, TWA3, mpp8, M-phase phosphoprotein 8
External IDs	OMIM: 611626 MGI: 1922589 HomoloGene: 11380 GeneCards: MPHOSPH8
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.11 Start 19,633,659 bp[1] End 19,673,441 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 56,668,248 bp[2] End 56,697,430 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methylated histone binding • GO:0001948 protein binding • ubiquitin protein ligase binding • ubiquitin-protein transferase activity • chromatin binding Cellular component • cytoplasm • nuclear heterochromatin • nuclear nucleosome • cell membrane • nucleolus • cell nucleus • chromosome • ubiquitin ligase complex • cytosol • heterochromatin Biological process • regulation of DNA methylation • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • protein ubiquitination • negative regulation of gene expression, epigenetic • positive regulation of methylation-dependent chromatin silencing • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54737	75339
Ensembl	ENSG00000196199	ENSMUSG00000079184
UniProt	Q99549	Q3TYA6
RefSeq (mRNA)	NM_017520	NM_023773 NM_001360072
RefSeq (protein)	NP_059990	NP_076262 NP_001347001
Location (UCSC)	Chr 13: 19.63 – 19.67 Mb	Chr 14: 56.67 – 56.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000196199 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079184 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
6. "Entrez Gene: HSMPP8 M-phase phosphoprotein, mpp8".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Maksimov VV, Arman IP, Tarantul VZ (2006). "[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]". Genetika. 42 (2): 274–7. PMID 16583711.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Umeda M, Nishitani H, Nishimoto T (2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303: 47–54. doi:10.1016/S0378-1119(02)01153-8. PMID 12559565.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.