MPHOSPH1

Kinesin-like protein KIF20B is a protein that in humans is encoded by the KIF20B gene.[5][6][7][8]

KIF20B
Identifiers
Aliases	KIF20B, CT90, KRMP1, MPHOSPH1, MPP-1, MPP1, kinesin family member 20B
External IDs	OMIM: 605498 MGI: 2444576 HomoloGene: 9418 GeneCards: KIF20B
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 89,701,610 bp[1] End 89,774,939 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 34,922,361 bp[2] End 34,975,745 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • microtubule motor activity • protein homodimerization activity • microtubule binding • ATPase activity • GO:0001948 protein binding • WW domain binding • ATP-dependent microtubule motor activity, plus-end-directed • ATP binding Cellular component • cytoplasm • centrosome • mitotic spindle pole • cell projection • spindle pole • contractile ring • kinesin complex • growth cone • microtubule cytoskeleton • spindle • nucleoplasm • microtubule organizing center • mitotic spindle midzone • axon • midbody • nucleolus • spindle midzone • perinuclear region of cytoplasm • microtubule • cytoskeleton • cell nucleus Biological process • positive regulation of intracellular protein transport • neuron projection morphogenesis • cell division • positive regulation of cytokinesis • positive regulation of neuron migration • microtubule-based movement • positive regulation of mitotic cytokinetic process • neural tube closure • protein localization to microtubule • regulation of establishment of protein localization • cell cycle arrest • positive regulation of cell proliferation • regulation of neuron migration • cell cycle • regulation of establishment of cell polarity • regulation of mitotic nuclear division Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9585	240641
Ensembl	ENSG00000138182	ENSMUSG00000024795
UniProt	Q96Q89	Q80WE4
RefSeq (mRNA)	NM_016195 NM_001284259 NM_001382506	NM_183046 NM_001362434
RefSeq (protein)	NP_001271188 NP_057279 NP_001369435	NP_898867 NP_001349363
Location (UCSC)	Chr 10: 89.7 – 89.77 Mb	Chr 19: 34.92 – 34.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MPHOSPH1 has been shown to interact with PIN1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138182 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024795 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
6. Westendorf JM, Rao PN, Gerace L (Feb 1994). "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope". Proc Natl Acad Sci U S A. 91 (2): 714–8. Bibcode:1994PNAS...91..714W. doi:10.1073/pnas.91.2.714. PMC 43019. PMID 8290587.
7. Kamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M (Oct 2001). "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1". J Biol Chem. 276 (40): 37520–8. doi:10.1074/jbc.M106207200. PMID 11470801.
8. "Entrez Gene: MPHOSPH1 M-phase phosphoprotein 1".

Further reading

• Fritzler MJ, Kerfoot SM, Feasby TE, et al. (2000). "Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)". J. Investig. Med. 48 (1): 28–39. PMID 10695267.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Abaza A, Soleilhac JM, Westendorf J, et al. (2003). "M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis". J. Biol. Chem. 278 (30): 27844–52. doi:10.1074/jbc.M304522200. PMC 2652640. PMID 12740395.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.