MORF4L2

Mortality factor 4-like protein 2 is a protein that in humans is encoded by the MORF4L2 gene.[5][6][7]

MORF4L2
Identifiers
Aliases	MORF4L2, MORFL2, MRGX, mortality factor 4 like 2
External IDs	OMIM: 300409 MGI: 1927167 HomoloGene: 22710 GeneCards: MORF4L2
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.2 Start 103,675,496 bp[1] End 103,688,158 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F1 Start 136,732,942 bp[2] End 136,743,690 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell membrane • nucleolus • cell nucleus • nucleoplasm • NuA4 histone acetyltransferase complex • histone acetyltransferase complex Biological process • histone H2A acetylation • chromatin remodeling • regulation of growth • chromatin silencing • regulation of transcription, DNA-templated • histone deacetylation • DNA repair • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of striated muscle cell differentiation • cellular response to DNA damage stimulus • histone H4 acetylation • chromatin organization • histone acetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9643	56397
Ensembl	ENSG00000123562	ENSMUSG00000031422
UniProt	Q15014	Q9R0Q4
RefSeq (mRNA)	NM_012286 NM_001142418 NM_001142419 NM_001142420 NM_001142421 NM_001142422 NM_001142423 NM_001142424 NM_001142425 NM_001142426 NM_001142427 NM_001142428 NM_001142429 NM_001142430 NM_001142431 NM_001142432	NM_001168225 NM_001168226 NM_001168227 NM_001168228 NM_001168229 NM_001168230 NM_019768
RefSeq (protein)	NP_001135890 NP_001135891 NP_001135892 NP_001135893 NP_001135894 NP_001135895 NP_001135896 NP_001135897 NP_001135898 NP_001135899 NP_001135900 NP_001135901 NP_001135902 NP_001135903 NP_001135904 NP_036418	NP_001161697 NP_001161698 NP_001161699 NP_001161700 NP_001161701 NP_001161702 NP_062742
Location (UCSC)	Chr X: 103.68 – 103.69 Mb	Chr X: 136.73 – 136.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000123562 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031422 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bertram MJ, Berube NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM (Feb 1999). "Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes". Mol Cell Biol. 19 (2): 1479–85. doi:10.1128/mcb.19.2.1479. PMC 116076. PMID 9891081.
6. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
7. "Entrez Gene: MORF4L2 mortality factor 4 like 2".

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Sakai K, Shirakawa T, Li Y, et al. (2002). "Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X". Mol. Cell. Neurosci. 19 (4): 477–84. doi:10.1006/mcne.2001.1059. PMID 11988016.
• Yochum GS, Ayer DE (2002). "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
• Tominaga K, Leung JK, Rookard P, et al. (2004). "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner". J. Biol. Chem. 278 (49): 49618–24. doi:10.1074/jbc.M309192200. PMID 14506250.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.