MORC2

MORC family CW-type zinc finger protein 2 is a protein that in humans is encoded by the MORC2 gene.[5][6]

MORC2
Identifiers
Aliases	MORC2, ZCW3, ZCWCC1, CMT2Z, MORC family CW-type zinc finger 2
External IDs	OMIM: 616661 MGI: 1921772 HomoloGene: 8966 GeneCards: MORC2
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,925,130 bp[1] End 30,968,774 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,649,191 bp[2] End 3,690,477 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • metal ion binding • GO:0001948 protein binding • magnesium ion binding • chromatin binding • ATP binding • ATPase activity • protein homodimerization activity • nucleotide binding • hydrolase activity Cellular component • cell nucleus • cytoplasm • cytosol • heterochromatin • nuclear matrix • chromosome Biological process • fatty acid metabolic process • lipid metabolism • cellular response to DNA damage stimulus • negative regulation of gene expression, epigenetic • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate • positive regulation of methylation-dependent chromatin silencing • chromatin remodeling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22880	74522
Ensembl	ENSG00000133422	ENSMUSG00000034543
UniProt	Q9Y6X9	Q69ZX6
RefSeq (mRNA)	NM_001303256 NM_001303257 NM_014941	NM_001159288 NM_198162 NM_001363202
RefSeq (protein)	NP_001290185 NP_001290186 NP_055756	NP_001152760 NP_937805 NP_001350131
Location (UCSC)	Chr 22: 30.93 – 30.97 Mb	Chr 11: 3.65 – 3.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000133422 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034543 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Perry J, Zhao Y (Nov 2003). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants". Trends Biochem Sci. 28 (11): 576–80. doi:10.1016/j.tibs.2003.09.007. PMID 14607086.
6. "Entrez Gene: MORC2 MORC family CW-type zinc finger 2".

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.