MMS19

MMS19 nucleotide excision repair protein homolog is a protein that in humans is encoded by the MMS19 gene.[5][6]

MMS19
Identifiers
Aliases	MMS19, MET18, MMS19L, hMMS19 homolog, cytosolic iron-sulfur assembly component, CIAO4
External IDs	OMIM: 614777 MGI: 1919449 HomoloGene: 41480 GeneCards: MMS19
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 97,458,324 bp[1] End 97,498,794 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 41,941,086 bp[2] End 41,981,157 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding, bridging • GO:0001105 transcription coactivator activity • GO:0001948 protein binding • enzyme binding • receptor signaling complex scaffold activity • estrogen receptor binding Cellular component • membrane • nucleoplasm • holo TFIIH complex • CIA complex • cytoskeleton • MMXD complex • cell nucleus • cytoplasm • spindle • cytosol Biological process • regulation of transcription, DNA-templated • chromosome segregation • DNA metabolic process • cellular response to DNA damage stimulus • positive regulation of transcription, DNA-templated • iron-sulfur cluster assembly • phosphorelay signal transduction system • response to hormone • DNA repair • nucleotide-excision repair • transcription, DNA-templated • protein maturation by iron-sulfur cluster transfer • positive regulation of double-strand break repair via homologous recombination • positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64210	72199
Ensembl	ENSG00000155229	ENSMUSG00000025159
UniProt	Q96T76	Q9D071
RefSeq (mRNA)	NM_001289403 NM_001289404 NM_001289405 NM_022362 NM_001330128 NM_001351356 NM_001351357 NM_001351358 NM_001351359	NM_028152 NM_001373946
RefSeq (protein)	NP_001276332 NP_001276333 NP_001276334 NP_001317057 NP_071757 NP_001338285 NP_001338286 NP_001338287 NP_001338288	NP_082428 NP_001360875
Location (UCSC)	Chr 10: 97.46 – 97.5 Mb	Chr 19: 41.94 – 41.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000155229 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025159 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seroz T, Winkler GS, Auriol J, Verhage RA, Vermeulen W, Smit B, Brouwer J, Eker AP, Weeda G, Egly JM, Hoeijmakers JH (Nov 2000). "Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases". Nucleic Acids Res. 28 (22): 4506–13. doi:10.1093/nar/28.22.4506. PMC 113875. PMID 11071939.
6. "Entrez Gene: MMS19L MMS19-like (MET18 homolog, S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wu X, Li H, Chen JD (2001). "The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor". J. Biol. Chem. 276 (26): 23962–8. doi:10.1074/jbc.M101041200. PMID 11279242.
• Queimado L, Rao M, Schultz RA, et al. (2002). "Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant". Nucleic Acids Res. 29 (9): 1884–91. doi:10.1093/nar/29.9.1884. PMC 37259. PMID 11328871.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hatfield MD, Reis AM, Obeso D, et al. (2006). "Identification of MMS19 domains with distinct functions in NER and transcription". DNA Repair (Amst.). 5 (8): 914–24. doi:10.1016/j.dnarep.2006.05.007. PMID 16797255.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.