ML domain
The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of immunoglobulin E-set domains. This domain is present in the following proteins:
- Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes.[1]
- House dust mite allergen proteins such as Der f 2 from Dermatophagoides farinae and Der p 2 from Dermatophagoides pteronyssinus.[2]
| ML domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 X-ray structure of Der p 2, the major house dust mite allergen | |||||||||
| Identifiers | |||||||||
| Symbol | E1_DerP2_DerF2 | ||||||||
| Pfam | PF02221 | ||||||||
| InterPro | IPR003172 | ||||||||
| SCOPe | 1a9v / SUPFAM | ||||||||
| OPM superfamily | 91 | ||||||||
| OPM protein | 1nep | ||||||||
| CDD | cd00912 | ||||||||
| |||||||||
Human proteins containing this domain
LY86; LY96; MMD-1;
gollark: The main problem I have with it is that it conflates readability (you can see what the code is doing at a low level) with comprehensibility (you know what and why it's doing at a higher one).
gollark: Are you being serious?
gollark: ~~Go is Not Good~~
gollark: Monoids.
gollark: ```Within the grove the mist thickened to a warm and bitter-tasting fog; from somewhere up ahead came the sound of bubbling water. The trees parted, and Djishin found himself in a clearing where four nuns in white robes sat contemplating a monolith of glistening black basalt. On its face were inscriptions such as the monk had never seen: (>>=) :: m a -> (a -> m b) -> m b return :: a -> m a“What is this stone, great ladies?” asked Djishin.“We call it the Monad,” said the first nun.“Why do you venerate it so?” asked Djishin.“Through it, we may touch the impure without being corrupted,” said the second nun. “We can fell a Maybe-tree with a Maybe-ax and always hear a Maybe-sound when it crashes down—even if the sound is Nothing at all, when the ax isn’t real or there’s no tree to fall.”```
References
- Lobel P, Stock AM, Friedland N, Liou HL (2003). "Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2512–2517. doi:10.1073/pnas.0437840100. PMC 151372. PMID 12591954.
- Kristensen O, Kastrup JS, Skov LK, Gajhede M, Larsen JN, Johannessen BR, Bolwig C, Spangfort M, Lund K (2005). "Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity". FEBS Lett. 579 (5): 1208–12. doi:10.1016/j.febslet.2004.11.115. PMID 15710415.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.