MHC class I polypeptide–related sequence B

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus.[5] MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.[5] MICB is a stress-induced ligand for NKG2D receptor.[6] The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.[7]

MICB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1JE6, 2WY3
Identifiers
Aliases	MICB, PERB11.2, MHC class I polypeptide-related sequence B
External IDs	OMIM: 602436 MGI: 2179989 HomoloGene: 88329 GeneCards: MICB
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,494,881 bp[1] End 31,511,124 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.35 cM Start 18,839,966 bp[2] End 18,865,402 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • natural killer cell lectin-like receptor binding Cellular component • integral component of membrane • cell surface • cell membrane • membrane • extracellular • external side of plasma membrane Biological process • immune system process • gamma-delta T cell activation • GO:0022415 viral process • response to heat • cytolysis • adaptive immune response • response to oxidative stress • response to retinoic acid • T cell mediated cytotoxicity • natural killer cell mediated cytotoxicity • regulation of immune response • immune response-activating cell surface receptor signaling pathway • immune response • natural killer cell activation • susceptibility to natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4277	243864
Ensembl	ENSG00000231179 ENSG00000224378 ENSG00000206449 ENSG00000227772 ENSG00000238289 ENSG00000231372 ENSG00000234218 ENSG00000204516	ENSMUSG00000040987
UniProt	Q29980	n/a
RefSeq (mRNA)	NM_001289160 NM_001289161 NM_005931	NM_153760 NM_153761
RefSeq (protein)	NP_001276089 NP_001276090 NP_005922	n/a
Location (UCSC)	Chr 6: 31.49 – 31.51 Mb	Chr 7: 18.84 – 18.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• MICA

References

1. ENSG00000224378, ENSG00000206449, ENSG00000227772, ENSG00000238289, ENSG00000231372, ENSG00000234218, ENSG00000204516 GRCh38: Ensembl release 89: ENSG00000231179, ENSG00000224378, ENSG00000206449, ENSG00000227772, ENSG00000238289, ENSG00000231372, ENSG00000234218, ENSG00000204516 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040987 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bahram S, Bresnahan M, Geraghty DE, Spies T (Jul 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6259–63. doi:10.1073/pnas.91.14.6259. PMC 44180. PMID 8022771.
6. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.
7. Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.

Further reading

• Braud VM, Allan DS, McMichael AJ (Feb 1999). "Functions of nonclassical MHC and non-MHC-encoded class I molecules". Current Opinion in Immunology. 11 (1): 100–8. doi:10.1016/S0952-7915(99)80018-1. PMID 10047540.
• Borrego F, Kabat J, Kim DK, Lieto L, Maasho K, Peña J, Solana R, Coligan JE (Feb 2002). "Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells" (PDF). Molecular Immunology. 38 (9): 637–60. doi:10.1016/S0161-5890(01)00107-9. PMID 11858820.
• Leelayuwat C, Townend DC, Degli-Esposti MA, Abraham LJ, Dawkins RL (1994). "A new polymorphic and multicopy MHC gene family related to nonmammalian class I". Immunogenetics. 40 (5): 339–51. doi:10.1007/BF01246675. PMID 7927538.
• Bahram S, Spies T (1996). "Nucleotide sequence of a human MHC class I MICB cDNA". Immunogenetics. 43 (4): 230–3. doi:10.1007/s002510050051. PMID 8575823.
• Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Jan 1996). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics. 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.
• Bahram S, Shiina T, Oka A, Tamiya G, Inoko H (1997). "Genomic structure of the human MHC class I MICB gene". Immunogenetics. 45 (2): 161–2. doi:10.1007/s002510050184. PMID 8952966.
• Gaudieri S, Leelayuwat C, Townend DC, Mullberg J, Cosman D, Dawkins RL (1997). "Allelic and interlocus comparison of the PERB11 multigene family in the MHC". Immunogenetics. 45 (3): 209–16. doi:10.1007/s002510050191. PMID 8995188.
• Pellet P, Renaud M, Fodil N, Laloux L, Inoko H, Hauptmann G, Debré P, Bahram S, Theodorou I (1997). "Allelic repertoire of the human MICB gene". Immunogenetics. 46 (5): 434–6. doi:10.1007/s002510050299. PMID 9271635.
• Ando H, Mizuki N, Ota M, Yamazaki M, Ohno S, Goto K, Miyata Y, Wakisaka K, Bahram S, Inoko H (1997). "Allelic variants of the human MHC class I chain-related B gene (MICB)". Immunogenetics. 46 (6): 499–508. doi:10.1007/s002510050311. PMID 9321430.
• Groh V, Steinle A, Bauer S, Spies T (Mar 1998). "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells". Science. 279 (5357): 1737–40. doi:10.1126/science.279.5357.1737. PMID 9497295.
• Visser CJ, Tilanus MG, Schaeffer V, Tatari Z, Tamouza R, Janin A, Charron D (Jun 1998). "Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles". Tissue Antigens. 51 (6): 649–52. doi:10.1111/j.1399-0039.1998.tb03008.x. PMID 9694358.
• Steinle A, Groh V, Spies T (Oct 1998). "Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules". Proceedings of the National Academy of Sciences of the United States of America. 95 (21): 12510–5. doi:10.1073/pnas.95.21.12510. PMC 22861. PMID 9770516.
• Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T (Jun 1999). "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6879–84. doi:10.1073/pnas.96.12.6879. PMC 22010. PMID 10359807.
• Tay GK, Hui J, Gaudieri S, Schmitt-Egenolf M, Martinez OP, Leelayuwat C, Williamson JF, Eiermann TH, Dawkins RL (Mar 2000). "PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis". Clinical and Experimental Immunology. 119 (3): 553–8. doi:10.1046/j.1365-2249.2000.01140.x. PMC 1905592. PMID 10691930.
• Fischer G, Pérez-Rodríguez M, Argüello JR, Cox ST, McWhinnie A, Travers PJ, Madrigal JA (Feb 2000). "Three novel MICB alleles". Tissue Antigens. 55 (2): 166–70. doi:10.1034/j.1399-0039.2000.550210.x. PMID 10746790.
• Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL (Jun 2000). "Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice". Immunity. 12 (6): 721–7. doi:10.1016/S1074-7613(00)80222-8. PMID 10894171.