MIB2 (gene)

E3 ubiquitin-protein ligase MIB2 is an enzyme that in humans is encoded by the MIB2 gene.[5][6]

MIB2
Identifiers
Aliases	MIB2, ZZANK1, ZZZ5, mindbomb E3 ubiquitin protein ligase 2
External IDs	OMIM: 611141 MGI: 2679684 HomoloGene: 16062 GeneCards: MIB2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.33 Start 1,615,415 bp[1] End 1,630,610 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 155,654,677 bp[2] End 155,669,198 bp[2]
Gene ontology Molecular function • signal transducer activity • zinc ion binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • actin binding • GO:0001948 protein binding • ubiquitin-protein transferase activity • transferase activity Cellular component • cytoplasm • endosome • early endosome • ubiquitin ligase complex • cytosol Biological process • Notch signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • protein ubiquitination • protein polyubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	142678	76580
Ensembl	ENSG00000197530	ENSMUSG00000029060
UniProt	Q96AX9	Q8R516
RefSeq (mRNA)	NM_001170686 NM_001170687 NM_001170688 NM_001170689 NM_080875	NM_001256107 NM_001256108 NM_001256110 NM_145124 NM_001369161 NM_001369162 NM_001369163 NM_001369164 NM_001369165 NM_001369166 NM_001369167 NM_001369168
RefSeq (protein)	NP_001164157 NP_001164158 NP_001164159 NP_001164160 NP_543151	NP_001243036 NP_001243037 NP_660106 NP_001356090 NP_001356091 NP_001356092 NP_001356093 NP_001356094 NP_001356095 NP_001356096 NP_001356097
Location (UCSC)	Chr 1: 1.62 – 1.63 Mb	Chr 4: 155.65 – 155.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MIB2 (gene) has been shown to interact with Actin, alpha 1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000197530 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029060 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
6. "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".
7. Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takeuchi T, Heng HH, Ye CJ, et al. (2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. PMC 1868282. PMID 14507647.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Koo BK, Yoon KJ, Yoo KW, et al. (2005). "Mind bomb-2 is an E3 ligase for Notch ligand". J. Biol. Chem. 280 (23): 22335–42. doi:10.1074/jbc.M501631200. PMID 15824097.
• Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma". DNA Cell Biol. 24 (5): 339–44. doi:10.1089/dna.2005.24.339. PMID 15869411.
• Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma". Am. J. Pathol. 166 (6): 1817–26. doi:10.1016/S0002-9440(10)62491-1. PMC 1602431. PMID 15920166.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Takeuchi T, Adachi Y, Sonobe H, et al. (2006). "A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion". Oncogene. 25 (53): 7059–69. doi:10.1038/sj.onc.1209688. PMID 16715130.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.