MGST2

Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.[5][6]

MGST2
Identifiers
Aliases	MGST2, GST2, MGST-II, microsomal glutathione S-transferase 2
External IDs	OMIM: 601733 MGI: 2448481 HomoloGene: 1811 GeneCards: MGST2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.1 Start 139,665,768 bp[1] End 139,740,745 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 C Start 51,660,360 bp[2] End 51,682,677 bp[2]
Gene ontology Molecular function • GO:0010577 enzyme activator activity • leukotriene-C4 synthase activity • transferase activity • glutathione transferase activity • GO:0001948 protein binding • glutathione peroxidase activity Cellular component • integral component of membrane • intracellular membrane-bounded organelle • organelle membrane • cell membrane • cytoplasm • endoplasmic reticulum membrane • endoplasmic reticulum • nuclear envelope • membrane Biological process • glutathione derivative biosynthetic process • leukotriene metabolic process • leukotriene biosynthetic process • glutathione biosynthetic process • response to lipopolysaccharide • GO:0048554 positive regulation of catalytic activity • response to organonitrogen compound • xenobiotic metabolic process • cellular oxidant detoxification • lipid metabolism • membrane lipid catabolic process • positive regulation of inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4258	211666
Ensembl	ENSG00000085871	ENSMUSG00000074604
UniProt	Q99735	A2RST1
RefSeq (mRNA)	NM_001204366 NM_001204367 NM_001204368 NM_002413	NM_174995 NM_001310482
RefSeq (protein)	NP_001191295 NP_001191296 NP_001191297 NP_002404	NP_001297411 NP_778160
Location (UCSC)	Chr 4: 139.67 – 139.74 Mb	Chr 3: 51.66 – 51.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000085871 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074604 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jakobsson PJ, Mancini JA, Ford-Hutchinson AW (Oct 1996). "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase". J Biol Chem. 271 (36): 22203–10. doi:10.1074/jbc.271.36.22203. PMID 8703034.
6. "Entrez Gene: MGST2 microsomal glutathione S-transferase 2".

Further reading

• Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J. Biol. Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.
• Jakobsson PJ, Scoggan KA, Yergey J, et al. (1998). "Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer". Journal of Lipid Mediators and Cell Signalling. 17 (1): 15–9. doi:10.1016/S0929-7855(97)00013-8. PMID 9302651.
• Sjöström M, Jakobsson PJ, Heimburger M, et al. (2001). "Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor". Eur. J. Biochem. 268 (9): 2578–86. doi:10.1046/j.1432-1327.2001.02142.x. PMID 11322876.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yang S, Yan KL, Zhang XJ, et al. (2006). "Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population". Arch. Dermatol. Res. 298 (3): 107–12. doi:10.1007/s00403-006-0670-4. PMID 16773312.