MFRP

Membrane frizzled-related protein is a protein that in humans is encoded by the MFRP gene.[5][6]

MFRP
Identifiers
Aliases	MFRP, MCOP5, NNO2, RD6, membrane frizzled-related protein, CTRP5
External IDs	OMIM: 606227 MGI: 2385957 HomoloGene: 12866 GeneCards: MFRP
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 119,338,942 bp[1] End 119,346,705 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.1|9 24.6 cM Start 44,101,729 bp[2] End 44,109,187 bp[2]
Gene ontology Molecular function • molecular function Cellular component • apical plasma membrane • integral component of membrane • cell membrane • membrane Biological process • visual perception • eye photoreceptor cell development • retina development in camera-type eye • embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83552	259172
Ensembl	ENSG00000235718	ENSMUSG00000034739
UniProt	Q9BY79	Q8K480
RefSeq (mRNA)	NM_031433	NM_001190314 NM_147126
RefSeq (protein)	NP_113621	NP_001177243 NP_667337
Location (UCSC)	Chr 11: 119.34 – 119.35 Mb	Chr 9: 44.1 – 44.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000235718 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034739 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M (Mar 2001). "Molecular cloning and characterization of MFRP, a novel gene encoding a membrane-type Frizzled-related protein". Biochem Biophys Res Commun. 282 (1): 116–23. doi:10.1006/bbrc.2001.4551. PMID 11263980.
6. "Entrez Gene: MFRP membrane frizzled-related protein".

Further reading

• Metlapally R, Li YJ, Tran-Viet KN, et al. (2008). "Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia". Mol. Vis. 14: 387–93. PMC 2268852. PMID 18334955.
• Ayala-Ramirez R, Graue-Wiechers F, Robredo V, et al. (2007). "A new autosomal recessive syndrome consisting of posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen is caused by a MFRP gene mutation". Mol. Vis. 12: 1483–9. PMID 17167404.
• Yang L, Yamasaki K, Shirakata Y, et al. (2006). "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". J. Dermatol. Sci. 42 (2): 111–9. doi:10.1016/j.jdermsci.2005.12.011. PMID 16442268.
• Pauer GJ, Xi Q, Zhang K, et al. (2006). "Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations". Ophthalmic Genet. 26 (4): 157–61. doi:10.1080/13816810500374425. PMID 16352475.
• Mandal MN, Heckenlively JR, Burch T, et al. (2005). "Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform". Invest. Ophthalmol. Vis. Sci. 46 (9): 3355–62. doi:10.1167/iovs.05-0007. PMID 16123440.
• Sundin OH, Leppert GS, Silva ED, et al. (2005). "Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein". Proc. Natl. Acad. Sci. U.S.A. 102 (27): 9553–8. doi:10.1073/pnas.0501451102. PMC 1172243. PMID 15976030.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hayward C, Shu X, Cideciyan AV, et al. (2004). "Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration". Hum. Mol. Genet. 12 (20): 2657–67. doi:10.1093/hmg/ddg289. PMID 12944416.