MFN1

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.[5][6][7]

MFN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T3J
Identifiers
Aliases	MFN1, hfzo1, hfzo2, mitofusin 1
External IDs	OMIM: 608506 MGI: 1914664 HomoloGene: 11481 GeneCards: MFN1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.33 Start 179,347,709 bp[1] End 179,394,936 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A3|3 15.75 cM Start 32,529,465 bp[2] End 32,579,239 bp[2]
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding • hydrolase activity • GTPase activity Cellular component • cytoplasm • mitochondrial outer membrane • mitochondrion • membrane • integral component of mitochondrial outer membrane • outer mitochondrial membrane protein complex • integral component of membrane • intrinsic component of mitochondrial outer membrane Biological process • mitochondrial fusion • macroautophagy • GTP metabolic process • mitochondrial membrane fusion • mitochondrion localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55669	67414
Ensembl	ENSG00000171109	ENSMUSG00000027668
UniProt	Q8IWA4	Q811U4
RefSeq (mRNA)	NM_017927 NM_033540	NM_024200
RefSeq (protein)	NP_284941	NP_077162
Location (UCSC)	Chr 3: 179.35 – 179.39 Mb	Chr 3: 32.53 – 32.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171109 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027668 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434.
6. Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci. 114 (Pt 5): 867–74. PMID 11181170.
7. "Entrez Gene: MFN1 mitofusin 1".

Further reading

• Pawlikowska P, Orzechowski A (2007). "[Role of transmembrane GTPases in mitochondrial morphology and activity]". Postepy Biochem. 53 (1): 53–9. PMID 17718388.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Hales KG, Fuller MT (1997). "Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase". Cell. 90 (1): 121–9. doi:10.1016/S0092-8674(00)80319-0. PMID 9230308.
• Chung JG, Yeh KT, Wu SL, et al. (2002). "Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display". Cancer Res. 61 (24): 8873–9. PMID 11751411.
• Rojo M, Legros F, Chateau D, Lombès A (2003). "Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo". J. Cell Sci. 115 (Pt 8): 1663–74. PMID 11950885.
• Legros F, Lombès A, Frachon P, Rojo M (2003). "Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins". Mol. Biol. Cell. 13 (12): 4343–54. doi:10.1091/mbc.E02-06-0330. PMC 138638. PMID 12475957.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Santel A, Frank S, Gaume B, et al. (2004). "Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells". J. Cell Sci. 116 (Pt 13): 2763–74. doi:10.1242/jcs.00479. PMID 12759376.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004). "OPA1 requires mitofusin 1 to promote mitochondrial fusion". Proc. Natl. Acad. Sci. U.S.A. 101 (45): 15927–32. doi:10.1073/pnas.0407043101. PMC 528769. PMID 15509649.
• Cartoni R, Léger B, Hock MB, et al. (2005). "Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise". J. Physiol. 567 (Pt 1): 349–58. doi:10.1113/jphysiol.2005.092031. PMC 1474174. PMID 15961417.