METTL3

N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene.[5]

METTL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IL0, 5IL2, 5IL1, 5K7M, 5K7U, 5K7W
Identifiers
Aliases	METTL3, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hMETTL3
External IDs	OMIM: 612472 MGI: 1927165 HomoloGene: 10501 GeneCards: METTL3
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 21,498,133 bp[1] End 21,511,342 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C2 Start 52,294,841 bp[2] End 52,305,128 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • RNA binding • RNA methyltransferase activity • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity • mRNA binding • S-adenosyl-L-methionine binding • protein heterodimerization activity • GO:0001948 protein binding • mRNA (N6-adenosine)-methyltransferase activity Cellular component • RNA N6-methyladenosine methyltransferase complex • nucleoplasm • nuclear speck • cell nucleus • cytoplasm Biological process • rhythmic process • mRNA processing • positive regulation of cap-independent translational initiation • stem cell population maintenance • primary miRNA methylation • methylation • mRNA methylation • mRNA destabilization • circadian rhythm • primary miRNA processing • adenosine to inosine editing • RNA methylation • mRNA splicing, via spliceosome • mRNA catabolic process • forebrain radial glial cell differentiation • cellular response to UV • gliogenesis • regulation of T cell differentiation • negative regulation of Notch signaling pathway • regulation of meiotic cell cycle • endothelial to hematopoietic transition • regulation of hematopoietic stem cell differentiation • cellular response to DNA damage stimulus • spermatogenesis • cell differentiation • dosage compensation by inactivation of X chromosome • RNA metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56339	56335
Ensembl	ENSG00000165819	ENSMUSG00000022160
UniProt	Q86U44	Q8C3P7
RefSeq (mRNA)	NM_019852	NM_019721
RefSeq (protein)	NP_062826	NP_062695
Location (UCSC)	Chr 14: 21.5 – 21.51 Mb	Chr 14: 52.29 – 52.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m⁶A).[5]

References

1. GRCh38: Ensembl release 89: ENSG00000165819 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022160 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: METTL3 methyltransferase like 3".

Further reading

• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bujnicki JM, Feder M, Radlinska M, Blumenthal RM (2003). "Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase". J. Mol. Evol. 55 (4): 431–44. doi:10.1007/s00239-002-2339-8. PMID 12355263.
• Leach RA, Tuck MT (2001). "Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells". Int. J. Biochem. Cell Biol. 33 (10): 984–99. doi:10.1016/S1357-2725(01)00071-1. PMID 11470232.
• Bokar JA, Shambaugh ME, Polayes D, et al. (1998). "Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase". RNA. 3 (11): 1233–47. PMC 1369564. PMID 9409616.