MESP1

Mesoderm posterior 1 homolog (mouse) is a protein that in humans is encoded by the MESP1 gene.[4] MESP1 is a transcription factor that regulates cardiovascular progenitor specification.[5]

MESP1
Identifiers
Aliases	MESP1, bHLHc5, mesoderm posterior bHLH transcription factor 1
External IDs	OMIM: 608689 MGI: 107785 HomoloGene: 32039 GeneCards: MESP1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 89,748,661 bp[1] End 89,751,310 bp[1]
Gene ontology Molecular function • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • Notch signaling pathway • neurogenesis • cardiac ventricle formation • regulation of transcription, DNA-templated • lateral mesoderm development • positive regulation of hepatocyte differentiation • positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway • negative regulation of mesodermal cell fate specification • cardiac muscle cell differentiation • positive regulation of Notch signaling pathway involved in heart induction • cardiac vascular smooth muscle cell differentiation • signal transduction involved in regulation of gene expression • heart morphogenesis • transcription from RNA polymerase II promoter • transcription, DNA-templated • sinus venosus morphogenesis • heart looping • positive regulation of transcription, DNA-templated • cardioblast migration • cardiac cell fate determination • multicellular organism development • gastrulation • embryonic heart tube morphogenesis • growth involved in heart morphogenesis • positive regulation of striated muscle cell differentiation • cardioblast migration to the midline involved in heart field formation • endothelial cell differentiation • sinoatrial node cell differentiation • negative regulation of endodermal cell fate specification • secondary heart field specification • cardiac atrium formation • negative regulation of transcription, DNA-templated • cardioblast anterior-lateral migration • mesodermal cell migration • positive regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter • mesoderm formation • somitogenesis • embryonic pattern specification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55897	17292
Ensembl	ENSG00000166823	n/a
UniProt	Q9BRJ9	P97309
RefSeq (mRNA)	NM_018670	NM_008588
RefSeq (protein)	NP_061140	NP_032614
Location (UCSC)	Chr 15: 89.75 – 89.75 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000166823 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Mesoderm posterior 1 homolog (mouse)".
5. Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, Blanpain C (July 2008). "Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification". Cell Stem Cell. 3 (1): 69–84. doi:10.1016/j.stem.2008.06.009. PMID 18593560.

Further reading

• David R, Brenner C, Stieber J, Schwarz F, Brunner S, Vollmer M, Mentele E, Müller-Höcker J, Kitajima S, Lickert H, Rupp R, Franz WM (March 2008). "MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling". Nature Cell Biology. 10 (3): 338–45. doi:10.1038/ncb1696. PMID 18297060.
• Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ (August 2012). "Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors". Proceedings of the National Academy of Sciences of the United States of America. 109 (32): 13016–21. doi:10.1073/pnas.1120299109. PMC 3420197. PMID 22826236.
• Saga Y, Hata N, Kobayashi S, Magnuson T, Seldin MF, Taketo MM (September 1996). "MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation". Development. 122 (9): 2769–78. PMID 8787751.
• Haraguchi S, Kitajima S, Takagi A, Takeda H, Inoue T, Saga Y (October 2001). "Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development". Mechanisms of Development. 108 (1–2): 59–69. doi:10.1016/S0925-4773(01)00478-6. PMID 11578861.