MEGARes
MEGARes is a hand-curated antibiotic resistance database for approximately 4000 resistant genes.[1] The database focuses on the analysis of large-scale, ecological sequence datasets with an annotation structure that allows for the development of high throughput acyclical classfiers and hierarchical statistical analysis of big data. MEGARes annotation consists of three hierarchical levels when looking at AMR genes: drug class, mechanism, and group. The MEGARes content was compiled from various other databases: Resfinder, ARG-ANNOT, Comprehensive Antibiotic Resistance Database (CARD), and the National Center for Biotechnology Information (NCBI) Lahey Clinic beta-lactamase archive.
Content | |
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Description | MEGARes is an antimicrobial resistance database made for high throughput sequencing based at Colorado State University |
Data types captured | Antimicrobial resistance genes and phenotypes |
Organisms | Bacteria |
Contact | |
Research center | Colorado State University |
Primary citation | PMID 27899569 |
Access | |
Website | http://megares.meglab.org |
Download URL | Download |
Miscellaneous | |
Bookmarkable entities | yes |
MEGARes allows users to analyze antimicrobial resistance on a population-level, similar to a microbiome analysis, from a FASTA sequence or keywords in their search bar. Furthermore, users can access AmrPlusplus, a pipeline for resistome analysis of metagenomic datasets that can be integrated with the MEGARes database.