MED30

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene.[4] It represents subunit Med30 of the Mediator complex and is metazoan-specific,[5] having no homologues in yeasts.

MED30
Identifiers
AliasesMED30, MED30S, THRAP6, TRAP25, mediator complex subunit 30
External IDsOMIM: 610237 MGI: 1917040 HomoloGene: 12329 GeneCards: MED30
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.11Start117,520,713 bp[1]
End117,540,262 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

90390

69790

Ensembl

ENSG00000164758

n/a

UniProt

Q96HR3

Q9CQI9

RefSeq (mRNA)

NM_001282986
NM_080651
NM_001363182

NM_027212

RefSeq (protein)

NP_001269915
NP_542382
NP_001350111

NP_081488

Location (UCSC)Chr 8: 117.52 – 117.54 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse
Med30
Identifiers
SymbolMed30
PfamPF11315
InterProIPR021019

Interactions

MED30 has been shown to interact with MED22.[6]

gollark: Create a new section "Bees" %bees.Create a rule "Bee utilization part 1" (%bees-1) in %bees:> The deployment status of bees is considered part of the Game State. No bee action (except for bee deployment) may be taken unless bees are currently deployed. Bee actions include deployment of bees, which makes bees become deployed, cessation of bees, which makes bees not be deployed, and use of bees against a player. The player bees are to be used against must be indicated in the Bee Poll authorizing this action. Use of bees against players causes their Points quantity to be reduced by 1, unless it is already 0, in which case there is no effect.Create a rule "Bee Poll" (%bee-poll) in %polls:> A Bee Poll is required to authorize bees to perform actions, as described in %bees. The default allowed reactions for a Bee Poll are 👍 (representing a vote for) and 👎 (representing a vote against). Bee Polls may be closed if they have existed for 12 hours or more, rather than the usual 24. If a Bee Poll is passed, the action it describes is taken. Players are permitted to use multiple reactions on a Bee Poll.Due to the passage of proposal #207, bees are to be considered "deployed" initially.
gollark: I've had to write up very precisely specified bee utilization/deployment rules for Quonauts, and I'm still worried there might be exploits!
gollark: ++delete the internet
gollark: You don't have to. You can just not do that.
gollark: It's a cool cheap software-defined radio thing.

References
  1. GRCh38: Ensembl release 89: ENSG00000164758 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6".
  5. Baek HJ, Malik S, Qin J, Roeder RG (Apr 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology. 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC 133729. PMID 11909976.
  6. Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.

Further reading


This article incorporates text from the public domain Pfam and InterPro: IPR021019
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