MED25
Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.[5][6][7]
Interactions
MED25 has been shown to interact with MED4.[8]
gollark: I think this is technically possible to implement, so bee⁻¹ you.
gollark: This is underspecified because bee² you, yes.
gollark: All numbers are two's complement because bee you.
gollark: The rest of the instruction consists of variable-width (for fun) target specifiers. The first N target specifiers in an operation are used as destinations and the remaining ones as sources. N varies per opcode. They can be of the form `000DDD` (pop/push from/to stack index DDD), `001EEE` (peek stack index EEE if source, if destination then push onto EEE if it is empty), `010FFFFFFFF` (8-bit immediate value FFFFFFFF; writes are discarded), `011GGGGGGGGGGGGGGGG` (16-bit immediate value GGGGGGGGGGGGGGGG; writes are also discarded), `100[H 31 times]` (31-bit immediate because bee you), `101IIIIIIIIIIIIIIII` (16 bits of memory location relative to the base memory address register of the stack the operation is conditional on), `110JJJJJJJJJJJJJJJJ` (16 bit memory location relative to the top value on that stack instead), `1111LLLMMM` (memory address equal to base memory address of stack LLL plus top of stack MMM), or `1110NNN` (base memory address register of stack MMM).Opcodes (numbered from 0 in order): MOV (1 source, as many destinations as can be parsed validly; the value is copied to all of them), ADD (1 destination, multiple sources), JMP (1 source), NOT (same as MOV), WR (write to output port; multiple sources, first is port number), RE (read from input port; one source for port number, multiple destinations), SUB, AND, OR, XOR, SHR, SHL (bitwise operations), MUL, ROR, ROL, NOP, MUL2 (multiplication with two outputs).
gollark: osmarksISA™️-2028 is a VLIW stack machine. Specifically, it executes a 384-bit instruction composed of 8 48-bit operations in parallel. There are 8 stacks, for safety. Each stack also has an associated base memory address register, which is used in some "addressing modes". Each stack holds 64-bit integers; popping/peeking an empty stack simply returns 0, and the stacks can hold at most 32 items. Exceeding a stack's capacity is runtime undefined behaviour. The operation encoding is: `AABBBCCCCCCCCC`:A = 2-bit conditional operation mode - 0 is "run unconditionally", 1 is "run if top value on stack is 0", 2 is "run if not 0", 3 is "run if first bit is ~~negative~~ 1".B = 3-bit index for the stack to use for the conditional.C = 9-bit opcode (for extensibility).
References
- GRCh38: Ensembl release 89: ENSG00000104973 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000002968 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- "Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)".
- Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Further reading
- Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (Apr 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
- Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (Aug 2002). "A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein". Biochemical and Biophysical Research Communications. 296 (2): 281–7. doi:10.1016/S0006-291X(02)00872-0. PMID 12163014.
- Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
- Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
- Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, Berti L, Meisterernst M (Dec 2003). "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells". The EMBO Journal. 22 (24): 6494–504. doi:10.1093/emboj/cdg619. PMC 291814. PMID 14657022.
- Yang F, DeBeaumont R, Zhou S, Näär AM (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2339–44. doi:10.1073/pnas.0308676100. PMC 356952. PMID 14983011.
- Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG (Jul 2005). "MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription". Molecular Cell. 19 (1): 89–100. doi:10.1016/j.molcel.2005.05.015. PMID 15989967.
- Lee HK, Park UH, Kim EJ, Um SJ (Aug 2007). "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation". The EMBO Journal. 26 (15): 3545–57. doi:10.1038/sj.emboj.7601797. PMC 1949011. PMID 17641689.
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