MED25

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.[5][6][7]

MED25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KY6, 2L6U, 2XNF, 2L23
Identifiers
Aliases	MED25, ACID1, ARC92, CMT2B2, P78, PTOV2, BVSYS, TCBAP0758, mediator complex subunit 25
External IDs	OMIM: 610197 MGI: 1922863 HomoloGene: 12614 GeneCards: MED25
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,818,279 bp[1] End 49,840,383 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.95 cM Start 44,876,765 bp[2] End 44,892,712 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transcription factor binding • GO:0001948 protein binding • retinoic acid receptor binding • retinoid X receptor binding Cellular component • cell nucleus • nucleoplasm • mediator complex Biological process • positive regulation of cell cycle arrest • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • positive regulation of chromatin binding • negative regulation of fibroblast proliferation • positive regulation of mediator complex assembly • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81857	75613
Ensembl	ENSG00000104973	ENSMUSG00000002968
UniProt	Q71SY5	Q8VCB2
RefSeq (mRNA)	NM_030973 NM_001378355	NM_029365 NM_001331206 NM_001331207 NM_001331208
RefSeq (protein)	NP_112235 NP_001365284	NP_001318135 NP_001318136 NP_001318137 NP_083641
Location (UCSC)	Chr 19: 49.82 – 49.84 Mb	Chr 7: 44.88 – 44.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MED25 has been shown to interact with MED4.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000104973 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002968 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. "Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)".
8. Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.

Further reading

• Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (Apr 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (Aug 2002). "A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein". Biochemical and Biophysical Research Communications. 296 (2): 281–7. doi:10.1016/S0006-291X(02)00872-0. PMID 12163014.
• Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
• Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
• Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, Berti L, Meisterernst M (Dec 2003). "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells". The EMBO Journal. 22 (24): 6494–504. doi:10.1093/emboj/cdg619. PMC 291814. PMID 14657022.
• Yang F, DeBeaumont R, Zhou S, Näär AM (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2339–44. doi:10.1073/pnas.0308676100. PMC 356952. PMID 14983011.
• Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
• Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG (Jul 2005). "MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription". Molecular Cell. 19 (1): 89–100. doi:10.1016/j.molcel.2005.05.015. PMID 15989967.
• Lee HK, Park UH, Kim EJ, Um SJ (Aug 2007). "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation". The EMBO Journal. 26 (15): 3545–57. doi:10.1038/sj.emboj.7601797. PMC 1949011. PMID 17641689.

External links

• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2