MED24

Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.[5]

MED24
Identifiers
AliasesMED24, ARC100, CRSP100, CRSP4, DRIP100, THRAP4, TRAP100, MED5, mediator complex subunit 24
External IDsOMIM: 607000 MGI: 1344385 HomoloGene: 40795 GeneCards: MED24
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.1Start40,019,097 bp[1]
End40,061,215 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9862

23989

Ensembl

ENSG00000008838

ENSMUSG00000017210

UniProt

O75448

Q99K74

RefSeq (mRNA)

NM_001079518
NM_001267797
NM_014815
NM_001330211

RefSeq (protein)

NP_001072986
NP_001254726
NP_001317140
NP_055630

Location (UCSC)Chr 17: 40.02 – 40.06 MbChr 11: 98.7 – 98.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Interactions

MED24 has been shown to interact with Estrogen receptor alpha,[6][7] Cyclin-dependent kinase 8,[7][8] Calcitriol receptor[6][8] and BRCA1.[9]

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References
  1. GRCh38: Ensembl release 89: ENSG00000008838 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017210 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4".
  6. Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
  7. Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
  8. Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
  9. Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681.

Further reading
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