MC3T3

MC3T3 is an osteoblast precursor cell line derived from Mus musculus (mouse) calvaria.[1]

A number of derivatives of this strain have been isolated to select for varying degrees of osteogenic potential, and have been widely used as model systems in bone biology. A standard textbook calls its MC3T3-E1 sub-line "one of the most convenient and physiologically relevant systems for study of transcriptional control in calvarial osteoblasts."[2] This a spontaneously transformed ( immortalized ) cell line. As such, it is a very convenient research tool but caution should be used when extrapolating these results to normal cells, and even more, to normal human cells.[3][4]

References
  1. Kodama H. A., Amagai Y., Sudo H., Kasai S., Yamamoto S. Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn J Oral Biol. 1981. Oct;23(4):899-901.
  2. Bilezikian, John P., Lawrence G. Raisz, and Gideon A. Rodan. Principles of Bone Biology. San Diego: Academic Press, 2002. p.1506
  3. Arriero, María del Mar; Ramis, Joana M.; Perelló, Joan; Monjo, Marta (2012). "Differential Response of MC3T3-E1 and Human Mesenchymal Stem Cells to Inositol Hexakisphosphate". Cellular Physiology and Biochemistry. 30 (4): 974–986. doi:10.1159/000341474. ISSN 1421-9778.
  4. Fernandes, Hugo; Dechering, Koen; van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Mentink, Anouk; van Blitterswijk, Clemens; de Boer, Jan (2010). "Effect of Chordin-Like 1 on MC3T3-E1 and Human Mesenchymal Stem Cells". Cells Tissues Organs. 191 (6): 443–452. doi:10.1159/000281825. ISSN 1422-6405.
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