MBOAT7

Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene.[5] It is homologous to other membrane-bound O-acyltransferases.

MBOAT7
Identifiers
Aliases	MBOAT7, BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7, membrane bound O-acyltransferase domain containing 7, MRT57, LPLAT
External IDs	OMIM: 606048 MGI: 1924832 HomoloGene: 11510 GeneCards: MBOAT7
EC number	2.3.1.n4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,173,412 bp[1] End 54,189,882 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 3,677,789 bp[2] End 3,693,523 bp[2]
Gene ontology Molecular function • transferase activity • transferase activity, transferring acyl groups • GO:0001948 protein binding • 2-acylglycerol-3-phosphate O-acyltransferase activity • 1-acylglycerol-3-phosphate O-acyltransferase activity • lysophospholipid acyltransferase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • ER-mitochondrion membrane contact site • endoplasmic reticulum Biological process • phosphatidylinositol acyl-chain remodeling • phosphatidylinositol metabolic process • ventricular system development • lipid metabolism • phospholipid biosynthetic process • phospholipid metabolic process • layer formation in cerebral cortex Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79143	77582
Ensembl	ENSG00000273592 ENSG00000278519 ENSG00000274194 ENSG00000125505 ENSG00000277025 ENSG00000275118 ENSG00000276935 ENSG00000277733 ENSG00000277923 ENSG00000278322	ENSMUSG00000035596
UniProt	Q96N66	Q8CHK3
RefSeq (mRNA)	NM_001146056 NM_001146082 NM_001146083 NM_024298	NM_029934
RefSeq (protein)	NP_001139528 NP_001139554 NP_001139555 NP_077274	NP_084210
Location (UCSC)	Chr 19: 54.17 – 54.19 Mb	Chr 7: 3.68 – 3.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle.[5]

References

1. ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 GRCh38: Ensembl release 89: ENSG00000273592, ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035596 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Membrane bound O-acyltransferase domain containing 7".

Further reading

• Wende H, Volz A, Ziegler A (July 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842.
• Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H (March 2008). "Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol". Mol. Biol. Cell. 19 (3): 1174–84. doi:10.1091/mbc.E07-09-0893. PMC 2262980. PMID 18094042.
• Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T (April 2009). "Recent progress on acyl CoA: lysophospholipid acyltransferase research". J. Lipid Res. 50 Suppl: S46–51. doi:10.1194/jlr.R800035-JLR200. PMC 2674719. PMID 18931347.
• Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR (October 2008). "Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils". J. Biol. Chem. 283 (44): 30235–45. doi:10.1074/jbc.M806194200. PMC 2573059. PMID 18772128.
• Fukunaga-Johnson N, Lee SW, Liebert M, Grossman HB (1996). "Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma". Anticancer Res. 16 (3A): 1085–90. PMID 8702217.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.