Ghrelin O-acyltransferase

Ghrelin O-acyltransferase (GOAT) also known as membrane bound O-acyltransferase domain containing 4 is an enzyme that in humans is encoded by the MBOAT4 gene.[5] It is homologous to other membrane-bound O-acyltransferases.

MBOAT4
Identifiers
Aliases	MBOAT4, GOAT, OACT4, FKSG89, membrane bound O-acyltransferase domain containing 4
External IDs	OMIM: 611940 MGI: 2685017 HomoloGene: 19272 GeneCards: MBOAT4
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 30,131,671 bp[1] End 30,144,665 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A4 Start 34,115,030 bp[2] End 34,125,182 bp[2]
Gene ontology Molecular function • transferase activity • serine O-acyltransferase activity • transferase activity, transferring acyl groups • O-acyltransferase activity Cellular component • integral component of membrane • integral component of endoplasmic reticulum membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • peptidyl-serine octanoylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	619373	234155
Ensembl	ENSG00000177669	ENSMUSG00000071113
UniProt	Q96T53	P0C7A3
RefSeq (mRNA)	NM_001100916	NM_001126314
RefSeq (protein)	NP_001094386	NP_001119786
Location (UCSC)	Chr 8: 30.13 – 30.14 Mb	Chr 8: 34.12 – 34.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000177669 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071113 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Membrane bound O-acyltransferase domain containing 4".

Further reading

• Gómez R, Lago F, Gómez-Reino JJ, Dieguez C, Gualillo O (June 2009). "Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes". Arthritis and Rheumatism. 60 (6): 1704–9. doi:10.1002/art.24522. PMID 19479831.
• Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE (April 2008). "Ghrelin octanoylation mediated by an orphan lipid transferase". Proceedings of the National Academy of Sciences of the United States of America. 105 (17): 6320–5. doi:10.1073/pnas.0800708105. PMC 2359796. PMID 18443287.
• Rodríguez A, Gómez-Ambrosi J, Catalán V, Rotellar F, Valentí V, Silva C, Mugueta C, Pulido MR, Vázquez R, Salvador J, Malagón MM, Colina I, Frühbeck G (November 2012). "The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes". Diabetologia. 55 (11): 3038–50. doi:10.1007/s00125-012-2671-5. PMID 22869322.
• Takahashi T, Ida T, Sato T, Nakashima Y, Nakamura Y, Tsuji A, Kojima M (November 2009). "Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid". Journal of Biochemistry. 146 (5): 675–82. doi:10.1093/jb/mvp112. PMID 19628676.
• Lim CT, Kola B, Grossman A, Korbonits M (2011). "The expression of ghrelin O-acyltransferase (GOAT) in human tissues". Endocrine Journal. 58 (8): 707–10. doi:10.1507/endocrj.k11e-117. PMID 21646729.
• Liu B, Garcia EA, Korbonits M (November 2011). "Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes". Peptides. 32 (11): 2191–207. doi:10.1016/j.peptides.2011.09.006. PMID 21930173.
• Heppner KM, Tong J, Kirchner H, Nass R, Tschöp MH (February 2011). "The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism". Current Opinion in Endocrinology, Diabetes and Obesity. 18 (1): 50–5. doi:10.1097/MED.0b013e328341e1d3. PMID 21150588.
• Müller TD, Tschöp MH, Jarick I, Ehrlich S, Scherag S, Herpertz-Dahlmann B, Zipfel S, Herzog W, de Zwaan M, Burghardt R, Fleischhaker C, Klampfl K, Wewetzer C, Herpertz S, Zeeck A, Tagay S, Burgmer M, Pfluger PT, Scherag A, Hebebrand J, Hinney A (May 2011). "Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa". Journal of Psychiatric Research. 45 (5): 706–11. doi:10.1016/j.jpsychires.2010.10.001. PMID 21035823.