MAZ (gene)

Myc-associated zinc finger protein is a protein that in humans is encoded by the MAZ gene.[5][6][7]

MAZ
Identifiers
Aliases	MAZ, PUR1, Pur-1, SAF-1, SAF-2, SAF-3, ZF87, ZNF801, Zif87, MYC associated zinc finger protein
External IDs	OMIM: 600999 MGI: 1338823 HomoloGene: 106451 GeneCards: MAZ
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,806,106 bp[1] End 29,811,164 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,022,130 bp[2] End 127,027,037 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • RNA polymerase II core promoter sequence-specific DNA binding • metal ion binding • nucleic acid binding • RNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • termination of RNA polymerase II transcription • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • positive regulation of cell proliferation • positive regulation of gene expression • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of cell migration • positive regulation of transcription, DNA-templated • positive regulation of protein kinase B signaling • negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4150	17188
Ensembl	ENSG00000103495	ENSMUSG00000030678
UniProt	P56270	P56671
RefSeq (mRNA)	NM_001042539 NM_001276275 NM_001276276 NM_002383	NM_010772 NM_001372521 NM_001372522 NM_001372523
RefSeq (protein)	NP_001036004 NP_001263204 NP_001263205 NP_002374	n/a
Location (UCSC)	Chr 16: 29.81 – 29.81 Mb	Chr 7: 127.02 – 127.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MAZ (gene) has been shown to interact with BPTF[8] and Deleted in Colorectal Cancer.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000103495 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030678 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pyrc JJ, Moberg KH, Hall DJ (May 1992). "Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter". Biochemistry. 31 (16): 4102–4110. doi:10.1021/bi00131a029. PMID 1567856.
6. Bossone SA, Asselin C, Patel AJ, Marcu KB (September 1992). "MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination". Proc Natl Acad Sci U S A. 89 (16): 7452–7456. doi:10.1073/pnas.89.16.7452. PMC 49728. PMID 1502157.
7. "Entrez Gene: MAZ MYC-associated zinc finger protein (purine-binding transcription factor)".
8. Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R (March 2000). "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity". Biochemistry. 39 (12): 3206–3215. doi:10.1021/bi992211q. PMC 3667205. PMID 10727212.
9. Ugai H, Li HO, Komatsu M, Tsutsui H, Song J, Shiga T, Fearon E, Murata T, Yokoyama KK (September 2001). "Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells". Biochem. Biophys. Res. Commun. 286 (5): 1087–1097. doi:10.1006/bbrc.2001.5469. PMID 11527412.

Further reading

• Parks CL, Shenk T (1996). "The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1". J. Biol. Chem. 271 (8): 4417–4430. doi:10.1074/jbc.271.8.4417. PMID 8626793.
• Tsutsui H, Sakatsume O, Itakura K, Yokoyama KK (1996). "Members of the MAZ family: a novel cDNA clone for MAZ from human pancreatic islet cells". Biochem. Biophys. Res. Commun. 226 (3): 801–809. doi:10.1006/bbrc.1996.1432. PMID 8831693.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Song J, Murakami H, Tsutsui H, Tang X, Matsumura M, Itakura K, Kanazawa I, Sun K, Yokoyama KK (1998). "Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ)". J. Biol. Chem. 273 (32): 20603–20614. doi:10.1074/jbc.273.32.20603. PMID 9685418.
• Song J, Murakami H, Yang ZQ, Koga C, Adati N, Murata T, Geltinger C, Saito-Ohara F, Ikeuchi T, Matsumura M, Itakura K, Kanazawa I, Sun K, Yokoyama KK (1998). "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2". Genomics. 52 (3): 374–377. doi:10.1006/geno.1998.5452. PMID 9790757.
• Tsutsui H, Geltinger C, Murata T, Itakura K, Wada T, Handa H, Yokoyama KK (1999). "The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II". Biochem. Biophys. Res. Commun. 262 (1): 198–205. doi:10.1006/bbrc.1999.1130. PMID 10448092.
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R (2000). "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity". Biochemistry. 39 (12): 3206–3215. doi:10.1021/bi992211q. PMC 3667205. PMID 10727212.
• Ugai H, Li HO, Komatsu M, Tsutsui H, Song J, Shiga T, Fearon E, Murata T, Yokoyama KK (2001). "Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells". Biochem. Biophys. Res. Commun. 286 (5): 1087–1097. doi:10.1006/bbrc.2001.5469. PMID 11527412.
• Ray BK, Murphy R, Ray P, Ray A (2003). "SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription". J. Biol. Chem. 277 (48): 46822–46830. doi:10.1074/jbc.M206299200. PMID 12270922.
• Bataller L, Wade DF, Graus F, Rosenfeld MR, Dalmau J (2004). "The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction". Ann. Neurol. 53 (1): 123–127. doi:10.1002/ana.10434. PMID 12509857.
• Ray A, Kuroki K, Cook JL, Bal BS, Kenter K, Aust G, Ray BK (2003). "Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis". Arthritis Rheum. 48 (1): 134–145. doi:10.1002/art.10706. PMID 12528113.
• Leroy C, Manen D, Rizzoli R, Lombès M, Silve C (2005). "Functional importance of Myc-associated zinc finger protein for the human parathyroid hormone (PTH)/PTH-related peptide receptor-1 P2 promoter constitutive activity". J. Mol. Endocrinol. 32 (1): 99–113. doi:10.1677/jme.0.0320099. PMID 14765995.
• Ray A, Shakya A, Kumar D, Ray BK (2004). "Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression". J. Immunol. 172 (8): 5006–5015. doi:10.4049/jimmunol.172.8.5006. PMID 15067082.
• Ray BK, Shakya A, Turk JR, Apte SS, Ray A (2005). "Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process". Circ. Res. 95 (11): 1082–1090. doi:10.1161/01.RES.0000150046.48115.80. PMID 15528467.
• Gromak N, West S, Proudfoot NJ (2006). "Pause sites promote transcriptional termination of mammalian RNA polymerase II". Mol. Cell. Biol. 26 (10): 3986–3996. doi:10.1128/MCB.26.10.3986-3996.2006. PMC 1488997. PMID 16648491.
• Ray A, Shakya A, Kumar D, Benson MD, Ray BK (2006). "Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis". J. Immunol. 177 (4): 2601–2609. doi:10.4049/jimmunol.177.4.2601. PMID 16888022.